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作者

Xiaohang Qin, Guanzhong Gong, Lizhen Wang, Ya Su, Yong Yin

作者单位

Affiliations ¹ Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China. ² Department of Radiation Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. ³ Department of Radiation Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. yinyongsd@12 com.

刊名

Radiation oncology (London, England)

年份

2022

卷号

Vol.17 No.1

页码

207

ISSN

1748-717X

关键词

Bone marrow sparing Cervical cancer MR functional imaging Pelvic active bone marrow Proton therapy.

摘要

Background: To segment the pelvic active bone marrow using magnetic resonance functional imaging and investigate the feasibility and dosimetric characteristics of cervical cancer proton radiotherapy for active bone marrow sparing. Methods: We collected CT and MR simulation images of 33 patients with cervical cancer retrospectively. The PBM was contoured on the MRI FatFrac images; the PBM was divided into high-active bone marrow and low-active bone marrow based on the fat content of the PBM. ...更多

Background: To segment the pelvic active bone marrow using magnetic resonance functional imaging and investigate the feasibility and dosimetric characteristics of cervical cancer proton radiotherapy for active bone marrow sparing. Methods: We collected CT and MR simulation images of 33 patients with cervical cancer retrospectively. The PBM was contoured on the MRI FatFrac images; the PBM was divided into high-active bone marrow and low-active bone marrow based on the fat content of the PBM. Four radiotherapy plans were created for each patient, which included intensity-modulated photon therapy , bone marrow sparing IMRT , intensity-modulated proton therapy , and bone marrow sparing IMPT . The dosimetric differences among the four plans were compared. Results: The ABM- volume in the enrolled patients accounted for 45.2% of the total ABM volume. The target coverage was similar among the four radiotherapy plans. IMRT-BMS, IMPT, and IMPT-BMS reduced the D of ABM- by 16.6%, 14.2%, and 44.5%, respectively, compared to the D of IMRT . Conclusions: The MR functional imaging technique helped in the grading and segmentation of PABM. MR functional image-guided proton radiotherapy for cervical cancer can achieve optimal BMS.收起

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