获取途径

作者

Jianfeng Peng Xiaoyan Yin Wenhua Yun Xiangjiao Meng Zhaoqin Huang

作者单位

²Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China ¹Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China

刊名

Cancer Letters

年份

2023

卷号

Vol.559

页码

216108

ISSN

0304-3835

关键词

Extracellular matrix Interstitial fluid pressure Radiation Immune checkpoint inhibitor Tumor physical microenvironment Drug delivery

摘要

The clinical benefits of immunotherapy are proven in many cancers, but a significant number of patients do not respond well to immunotherapy. The tumor physical microenvironment has recently been shown to affect the growth, metastasis and treatment of solid tumors. The tumor microenvironment has unique physical hallmarks: 1) unique tissue microarchitecture, 2) increased stiffness, 3) elevated solid stress, and 4) elevated interstitial fluid pressure , which contribute to tumor progression and ...更多

The clinical benefits of immunotherapy are proven in many cancers, but a significant number of patients do not respond well to immunotherapy. The tumor physical microenvironment has recently been shown to affect the growth, metastasis and treatment of solid tumors. The tumor microenvironment has unique physical hallmarks: 1) unique tissue microarchitecture, 2) increased stiffness, 3) elevated solid stress, and 4) elevated interstitial fluid pressure , which contribute to tumor progression and immunotherapy resistance in a variety of ways. Radiotherapy, a traditional and powerful treatment, can remodel the matrix and blood flow associated with the tumor to improve the response rate of immune checkpoint inhibitors to a certain extent. Herein, we first review the recent research advances on the physical properties of the TME and then explain how TpME is involved in immunotherapy resistance. Finally, we discuss how radiotherapy can remodel TpME to overcome immunotherapy resistance.收起

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