Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

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作者单位: ²Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China ¹Shandong Mental Health Center, Shandong University, Jinan, Shandong 250014, China

关键词: Depressão Acidente Vascular Cerebral Depressão/epidemiologia Depressão/etiologia Humanos Microglia Acidente Vascular Cerebral/complicações Acidente Vascular Cerebral/epidemiologia

摘要: Poststroke depression does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system t...更多; Poststroke depression does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.收起

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