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作者

Yue Hu Ying Zhang Yutong Liu Yan Gao Tiantian San Xiaoying Li Sensen Song Binglong Yan Zhuo Zhao

作者单位

²Department of Cardiology, Central Hospital Affiliated Shandong First Medical University, Jinan, China ¹Department of Cardiology, Jinan Central Hospital, Shandong University, Jinan, China ³Department of Research Center of Translational Medicine, Central Hospital Affiliated Shandong First Medical University, Jinan, China ⁴Department of Emergency, Central Hospital Affiliated Shandong First Medical University, Jinan, China

刊名

Frontiers in Cardiovascular Medicine

年份

2022

卷号

Vol.9

页码

905151

ISSN

2297-055X

关键词

single-cell RNA sequencing cardiovascular heart development stem cells precision medicine

摘要

Single-cell RNA sequencing provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and identifying targets for disease treatment. In recent years, emerging single-cell RNA sequencing technologies have been used to make breakthroughs regarding decoding developmental trajectories, phenotypic transitions, and cellular interactions in the cardiovascular ...更多

Single-cell RNA sequencing provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and identifying targets for disease treatment. In recent years, emerging single-cell RNA sequencing technologies have been used to make breakthroughs regarding decoding developmental trajectories, phenotypic transitions, and cellular interactions in the cardiovascular system, providing new insights into cardiovascular disease. This paper reviews the technical processes of single-cell RNA sequencing and the latest progress based on single-cell RNA sequencing in the field of cardiovascular system research, compares single-cell RNA sequencing with other single-cell technologies, and summarizes the extended applications and advantages and disadvantages of single-cell RNA sequencing. Finally, the prospects for applying single-cell RNA sequencing in the field of cardiovascular research are discussed.收起

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