获取途径

作者

Zhang, Xiaodong Li, Shuangjie Ren, Xiaolei Xiang, Peng Zhang, Yankun Wang, Tixiao Qin, Qinghua Sun, Fengkai Liu, Jingkang Gao, Lifen Ma, Chunhong Yue, Xuetian Yang, Xiaoyun Han, Shuang Liang, Xiaohong

作者单位

¹Depertment of Central Laboratory and Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China ²Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Cheeloo College of Medicine, Shandong University, Jinan, China ³Key Laboratory for Experimental Teratology of Ministry of Education and Department of Cell Biology, Cheeloo College of Medicine, Shandong University, Jinan, China ⁴Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China ⁵Department of Gynecology, Qilu Hospital of Shandong University, Jinan, China ⁶Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, China ⁷Department of Gastroenterology, Honghui Hospital, Xi'an Jiaotong University,, China

刊名

FEBS Journal

年份

2023

卷号

Vol.290 No.4

页码

1117-1133

ISSN

1742-464X

关键词

FoxO1 liver regeneration ROS TIPE1

摘要

The strong regenerative ability of the liver safeguards the crucial hepatic functions. The balance between hepatocyte proliferation and death is critical for restoring liver size and physiology. Tumour necrosis factor alpha‐induced protein 8‐like 1 is highly expressed in liver and has been identified as a candidate regulator for cell proliferation and death, being involved in a variety of biological processes and diseases. However, the role of TIPE1 in liver regeneration remains unexplored. In...更多

The strong regenerative ability of the liver safeguards the crucial hepatic functions. The balance between hepatocyte proliferation and death is critical for restoring liver size and physiology. Tumour necrosis factor alpha‐induced protein 8‐like 1 is highly expressed in liver and has been identified as a candidate regulator for cell proliferation and death, being involved in a variety of biological processes and diseases. However, the role of TIPE1 in liver regeneration remains unexplored. In the present study, we found that TIPE1 expression was elevated in the regenerating liver induced by either partial hepatectomy or 10% carbon tetrachloride administration. Mice with hepatocyte conditional Tipe1 knockout presented significantly impaired liver regeneration. Mechanistically, hepatic Tipe1 deficiency decreased the level of reactive oxygen species in hepatocytes, which in turn led to the inhibition of Forkhead box O1 acetylation and microtubule‐associated protein 1 light chain 3 I to microtubule‐associated protein 1 light chain 3 II conversion, and the accumulation of sequestosome 1. By contrast, forced expression of TIPE1 in hepatocyte significantly promoted liver regeneration following 70% partial hepatectomy and enhanced hepatocyte reactive oxygen species/acetylated‐Forkhead box O1 level and autophagy. These findings indicate that TIPE1 plays a crucial role in liver regeneration by finely regulating the oxidative stress and autophagy and is a potential target for medical intervention of liver regeneration.收起

文献类型

期刊