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作者

Yalan Wang Maoshun Liu Yuanyuan Guo Min Li Peipei Guo Wenjun He Tian Ma Peipei Liu Yaxin Guo Beiwei Ye Jun Liu Guizhen Wu

作者单位

⁵School of Public Health and Management, Shandong First Medical University &Shandong Academy of Medical Sciences, Jinan 250117, China ²These authors contributed equally to this work. ⁴Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Shandong 250100, China ⁶Given their role as Editor-in-Chief and Associate Editor-in-Chief, Guizhen Wu and Jun Liu had no involvement in the peer-review of this article and had no access to information regarding peer review. Full responsibility for the editorial process of this article was delegated to Editor Di Qu. ³College of Life Sciences, Beijing Normal University, Beijing 100875, China ¹NHC Key Laboratory of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China

刊名

Biosafety and Health

年份

2024

ISSN

2590-0536

关键词

SARS-CoV-2 Disorders Reinfection China

摘要

The effects of severe acute respiratory syndrome coronavirus 2 infection persist months and years after recovery. We conducted an online survey to assess the health condition of convalescents approximately 5 months following the primary infection of SARS-CoV-2. The study recruited 5,510 individuals who were primary infected, 626 participants who had experienced reinfection, and 521 participants who were without infective history. The most common disorders after the primary infection group were ...更多

The effects of severe acute respiratory syndrome coronavirus 2 infection persist months and years after recovery. We conducted an online survey to assess the health condition of convalescents approximately 5 months following the primary infection of SARS-CoV-2. The study recruited 5,510 individuals who were primary infected, 626 participants who had experienced reinfection, and 521 participants who were without infective history. The most common disorders after the primary infection group were fatigue , memory issue , post-exertional malaise , and brain fog . In addition, SARS-CoV-2 infection had an impact on the reproductive systems. In stepwise logistic regression analysis, smoking currently, with background diseases, and outpatient visits in the acute phase could be associated with moderate/severe disorders. Further analysis of different background diseases showed that allergic rhinitis, hyperlipidemia, cardiovascular disease, autoimmune diseases, neurological diseases, and asthma likely increased the risk of moderate/severe disorders. The probability of developing disorders of individuals with SARS-CoV-2 reinfection was higher before the secondary infection than uninfected people. Fatigue, PEM, muscle pain/spasms, chills, joint pain, excessive sweating at rest, headache/dizziness, sore throat or foreign body sensation in the throat, cough, expectoration, dry/painful/watery eyes, loss of appetite and constipation were associated with an increased risk of reinfection. It was essential to undertake further research with enhanced randomization in a larger sample in the community, and to strengthen the validation of the research conclusions. The findings of this study contribute to a deeper understanding of the health recovery process among coronavirus disease 2019 convalescents. Moreover, the findings help identify characteristic health risk factors associated with convalescents and highlight the risk of moderate/ severe disorders and reinfection. Furthermore, the findings also provide valuable guidance and reference for SARS-CoV-2 rehabilitation strategies and the prevention of reinfection, offering insights for scientific recommendations收起

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