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作者

Huizhen Song, Shuang Zhang, Qianqian Xie, Zhoujie Zhu, Linger Li, Hongqin Zhao

作者单位

Affiliations ¹ Department of Neurology, The Third People's Hospital of Heze, Heze, 274000, Shandong, China Department of Neurology, The Affiliated Hospital of Qingdao Univeisity, Qingdao, 266000, Shandong, China. ² Department of Cardiology, Heze Traditional Chinese Medicine Hospital, Heze, 274000, Shandong, China. ³ Department of Neurology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250000, Shandong, China. ⁴ Medical Department,The Third People's Hospital of Heze, Heze, 274000, Shandong, China. ⁵ Department of Neurology, The Affiliated Hospital of Qingdao Univeisity, Qingdao, 266000, Shandong, China. ⁶ Department of Neurology, The Affiliated Hospital of Qingdao Univeisity, Qingdao, 266000, Shandong, China. Electronic address: zhaohongq@qdu.edu.cn.

刊名

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

年份

2025

页码

108223

ISSN

1532-8511

关键词

Cryptogenic stroke patients Magnetic Resonance Imaging Right-to-left shunts The white matter hyperintensities cerebrovascular reactivity.

摘要

Objective: This study investigates cerebrovascular reactivity changes in cryptogenic stroke patients with right-to-left shunts and evaluates the relationship between CVR and white matter hyperintensities . Methods: The breath-holding index , representing CVR, was measured from the middle cerebral artery using the breath-holding method. WMHs were defined as clearly hyperintense areas on 3T magnetic resonance imaging , assessed separately as periventricular hyperintensities and deep white mat...更多

Objective: This study investigates cerebrovascular reactivity changes in cryptogenic stroke patients with right-to-left shunts and evaluates the relationship between CVR and white matter hyperintensities . Methods: The breath-holding index , representing CVR, was measured from the middle cerebral artery using the breath-holding method. WMHs were defined as clearly hyperintense areas on 3T magnetic resonance imaging , assessed separately as periventricular hyperintensities and deep white matter hyperintensities . RLS was diagnosed based on a contrast-enhanced transcranial Doppler examination. Results: Among 260 CS patients and 128 controls, BHI was significantly lower in CS groups , particularly in those with RLS . CS patients with WMHs exhibited lower BHI than those without WMHs , and PVH showed lower BHI compared to DWMH . A negative correlation was found between WMH severity and BHI . Reduced BHI was an independent risk factor for WMHs . Conclusion: CS patients, especially those with RLS, show reduced CVR, which correlates with the location and severity of WMHs. These findings suggest that RLS may significantly contribute to WMH development in CS patients.收起

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