CXCL12/CXCR4 axis mediates CD8 T cell overactivation in the progression of viral myocarditis
- 作者单位
- com. 10 Medical Science and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China. hanbo35@16 com. 8 Shandong Provincial Clinical Research Center for Children's Health and Disease office, Shandong Provincial Hospital, Jinan, Shandong, China. hanbo35@16 com. 9 Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. hanbo35@16 com. 7 Department of Pediatric Cardiology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China. hanbo35@16 Affiliations 1 Department of Pediatric Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. 2 Shandong Provincial Clinical Research Center for Children's Health and Disease office, Shandong Provincial Hospital, Jinan, Shandong, China. 3 Medical Science and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China. 4 Department of Pediatric Cardiology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China. 5 Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. 6 Department of Pediatric Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. hanbo35@16 com.
- 刊名
- Journal of translational medicine
- 年份
- 2025
- 卷号
- Vol.23 No.1
- 页码
- 399
- ISSN
- 1479-5876
- 摘要
- Background: Myocarditis is a common inflammatory heart disease in children and young adults, with fulminant myocarditis being the most severe form due to its rapid onset and high mortality rate. However, the precise pathological immune subsets and molecular change in myocarditis, particularly FM, remain unknown. Methods: We performed single-cell RNA sequencing of pediatric peripheral blood mononuclear cells during the acute and recovery phases of FM. A viral myocarditis mouse model was establi...更多
- 文献类型
- 期刊
- 浏览量
- 2
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被引次数
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