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作者

Wu, Peipei Xing, Xiaoli Huan, Yu Li, Xinying Yang, Yunhan Zhang, Jing Ma, Xiubin Li, Jun

作者单位

¹Shandong First Medical University ²Shandong First Medical University & Shandong Academy of Medical Sciences

刊名

Ocular Immunology & Inflammation

年份

2024

页码

1-7

ISSN

0927-3948

关键词

Acute retinal necrosis herpes zoster virus intravitreal dexamethasone implants macular edema optical coherence tomography

摘要

PurposeMethodsResultsConclusion\nSUMMARY STATEMENTTo assess the effectiveness and risk of intravitreal injection of dexamethasone implants in treating macular edema secondary to acute retinal necrosis .In this retrospective, noncomparative case series study, five patients who developed secondary ME after ARN and received an intravitreal dexamethasone implant injection were enrolled. The features of secondary ME on OCT and the outcomes of dexamethasone intravitreal implanting were presented.The ...更多

PurposeMethodsResultsConclusion\nSUMMARY STATEMENTTo assess the effectiveness and risk of intravitreal injection of dexamethasone implants in treating macular edema secondary to acute retinal necrosis .In this retrospective, noncomparative case series study, five patients who developed secondary ME after ARN and received an intravitreal dexamethasone implant injection were enrolled. The features of secondary ME on OCT and the outcomes of dexamethasone intravitreal implanting were presented.The mean age of the patients was 59 years . All patients had unilateral involvement, and all 5 eyes showed mild to moderate anterior uveitis, retinal necrosis, and vasculitis. Herpes zoster virus was detected in all eyes using PCR, and timely antiviral and anti-inflammatory treatment was performed. Aqueous humor samples were negative for herpes zoster virus DNA, and resolution of viral retinitis was noted upon the occurrence of ME. Additionally, three eyes received pars plana vitrectomy with silicone oil prior to ME development. All eyes presented with intraretinal fluid, hyper-reflective foci, and impairments of the external limiting membrane/ellipsoid zone at varying degrees on OCT images. Epiretinal membrane was exhibited in 80% of eyes, but no vitreoretinal traction was detected. Subretinal fluid was visible in 60% of eyes. ME was relieved effectively in all eyes after intravitreal dexamethasone implanting. One of these patients experienced three episodes of ME. No recurrence of retinal necrosis or corticosteroid-associated ocular hypertension was observed during the follow-up period.Intravitreal injection of dexamethasone implants can effectively alleviate ME secondary to ARN and improve visual acuity with no adverse reactions.Macular edema secondary to acute retinal necrosis was characterized by the presence of intraretinal fluid, hyper-reflective foci, and external limiting membrane/ellipsoid zone fracture. The intravitreal injection of dexamethasone implants effectively alleviated this type of edema with no adverse reactions.收起

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