Research Progress of Levosimendan in Cardiovascular Diseases

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关键词: 左西孟旦心血管疾病安全性和有效性 Levosimendan Cardiovascular Disease Efficacy and Safety

摘要: Levosimendan , as a new calcium sensitizer, can increase myocardial contractility, dilate pe-ripheral and coronary arteries, and protect organs such as liver, kidney and lung. Animal experi-ments have found that LS also has anti-inflammatory, anti-oxidation, anti-thrombosis and profibri-nolytic effects. LS is characterized by enhancing myocardial contractility without increasing myo-cardial oxygen consumption and having no effect on diastolic capacity. It is suitable for the short-term treatment...更多; Levosimendan , as a new calcium sensitizer, can increase myocardial contractility, dilate pe-ripheral and coronary arteries, and protect organs such as liver, kidney and lung. Animal experi-ments have found that LS also has anti-inflammatory, anti-oxidation, anti-thrombosis and profibri-nolytic effects. LS is characterized by enhancing myocardial contractility without increasing myo-cardial oxygen consumption and having no effect on diastolic capacity. It is suitable for the short-term treatment of Acute Decompensated Heart Failure that needs to increase myo-cardial contractility. In addition, LS can significantly improve cardiac function and relieve clinical symptoms in patients with cardiogenic shock, septic shock, pulmonary heart disease, dilated car-diomyopathy and surgical perioperative period.收起

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