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作者

舒 政 赵雪娜 张馨蕾 朱本朔 周清林 张 梅

作者单位

山东第一医科大学(山东省医学科学院)研究生院，山东 济南 山东第一医科大学第一附属医院(山东省千佛山医院)普通外科，山东第一医科大学第一附属医院腹腔镜技术实验室，山东省医药卫生普外中心重点实验室，山东 济南 山东第一医科大学第一附属医院乳腺外科，山东 济南

刊名

Advances in Clinical Medicine

年份

2024

卷号

Vol.14 No.12

页码

1244-1253

ISSN

2161-8712

关键词

白蛋白结合型紫杉醇 乳腺癌 病理完全缓解 临床疗效 Nab-Paclitaxel Breast Cancer Pathologic Complete Response Clinical Efficacy

摘要

Objective: To compare the efficacy of albumin-bound paclitaxel with docetaxel in neoadjuvant chemotherapy of tri-negative breast carcinoma and to confirm the superiority of albumin-bound paclitaxel in neoadjuvant chemotherapy of tri-negative breast carcinoma. Methods: In this retrospective analysis, we analyzed the data of triple-negative breast carcinoma treated with neoadjuvant chemotherapy and radical operation in Qianfoshan Hospital from January 2018 to December 2020. Based on the new adjuva...更多

Objective: To compare the efficacy of albumin-bound paclitaxel with docetaxel in neoadjuvant chemotherapy of tri-negative breast carcinoma and to confirm the superiority of albumin-bound paclitaxel in neoadjuvant chemotherapy of tri-negative breast carcinoma. Methods: In this retrospective analysis, we analyzed the data of triple-negative breast carcinoma treated with neoadjuvant chemotherapy and radical operation in Qianfoshan Hospital from January 2018 to December 2020. Based on the new adjuvant chemotherapy drugs the patients received, the patients were divided into the albumin-binding cisplatin group and the dosicisplatin group , the pathology, clinical efficacy, incidence of adverse reactions and survival of the two groups were analysed and evaluated. Results: There was no significant difference in clinical remission rate between the two groups . The pathologic complete remission rate of albumin binding paclitaxel group was significantly higher than that of docetaxel group . Further subgroup analyses revealed that histologic grade, lymph node status, Ki-67 score, and tumor stage were important predictors of treatment outcome. However, multivariate analysis showed that therapeutic drugs and histological grade were important factors affecting treatment outcome. With regard to adverse reactions, patients in the albumin-binding paclitaxel group had a lower risk of hepatic dysfunction and gastrointestinal reactions . Analysis of patient survival revealed that patients with albumin-binding paclitaxel regimens had longer survival . Conclusion: Compared with docetaxel, albumin-bound paclitaxel has better pathological efficacy, lower risk of liver injury and gastrointestinal response, and better prognosis for patients with triple-negative breast carcinoma.收起

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