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作者

张馨蕾 赵雪娜 舒 政 张 梅

作者单位

山东第一医科大学第一附属医院(山东省千佛山医院)乳腺外科，山东 济南 山东第一医科大学(山东省医学科学院)研究生院，山东 济南 山东第一医科大学第一附属医院(山东省千佛山医院)普通外科学，山东第一医科大学第一附属医院腹腔镜技术实验室，山东省医药卫生普外中心重点实验室，山东 济南

刊名

Advances in Clinical Medicine

年份

2024

卷号

Vol.14 No.3

页码

142-148

ISSN

2161-8712

关键词

核因子κB激活蛋白 核因子κB 肿瘤 机制 NF-κB Activating Protein NF-κB Tumor Mechanism

摘要

NKAP is a highly conserved 47kD protein that plays important roles in transcriptional suppression, T cell development, maturation and functional acquisition, maintenance and survival of hematopoietic stem cells, and RNA splicing. In recent years, more and more studies have been conducted on the relationship between NKAP and the occurrence and development of diseases, such as pneumonia, lung cancer, breast cancer, hepatocellular carcinoma, colon cancer, renal cell carcinoma, etc. Most research re...更多

NKAP is a highly conserved 47kD protein that plays important roles in transcriptional suppression, T cell development, maturation and functional acquisition, maintenance and survival of hematopoietic stem cells, and RNA splicing. In recent years, more and more studies have been conducted on the relationship between NKAP and the occurrence and development of diseases, such as pneumonia, lung cancer, breast cancer, hepatocellular carcinoma, colon cancer, renal cell carcinoma, etc. Most research results indicate that NKAP plays a role as an oncogene in tumor diseases, promoting cell proliferation, invasion, and migration. However, current research on NKAP in diseases is still relatively limited. This article mainly reviews the research status of NKAP in recent years.收起

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