One Case Report of Giant Mediastinal Spindle Cell Tumor with NTRK Rearrangement

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关键词: 神经原肌球蛋白相关激酶梭形细胞瘤纵膈肿物 NTRK Rearrangement Spindle Cell Neoplasm Mediastinum

摘要: Neurotropomyosin-related kinase rearranged spindle cell neoplasm represents a new group of tumors included in the fifth edition of the World Health Organization classification of soft tissue and bone sarcomas. To date, few cases of NTRK-rearranged SCN in the mediastinum in the mediastinum have been reported. Herein we present a case of a giant NTRK rearranged SCN in the right thoracic cavity removed through a special thoracotomy that preserves the rib. The neoplasm was removed surgically and...更多; Neurotropomyosin-related kinase rearranged spindle cell neoplasm represents a new group of tumors included in the fifth edition of the World Health Organization classification of soft tissue and bone sarcomas. To date, few cases of NTRK-rearranged SCN in the mediastinum in the mediastinum have been reported. Herein we present a case of a giant NTRK rearranged SCN in the right thoracic cavity removed through a special thoracotomy that preserves the rib. The neoplasm was removed surgically and was pathologically diagnosed as a spindle cell tumor. Immunohistochemistry results showed that smooth muscle actin , S100, CD34 and NTRK were positively expressed in tumor tissue. By discussing the pathologic types, diagnosis and treatment of the disease, we can provide more references for clinical diagnosis and treatment of this disease.收起

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