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作者

Zhou, Penglin Li, Anan Gao, Rui Zong, Huiying Li, Yan

作者单位

^bShandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Department of Clinical Pharmacy, First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China ^aDepartment of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

刊名

Drugs and Clinic

年份

2025

卷号

Vol.40 No.8

页码

1947-1953

ISSN

1674-5515

关键词

BMI FPG HDL-C MATE1 metformin OCT1 type 2 diabetes

摘要

Objective To investigate the effect of organic cation transporter 1 and multidrug and toxin efflux transporter 1 gene polymorphisms on blood glucose indicators in type 2 diabetes patients treated with metformin. Methods Using the cross-sectional study method, all participants diagnosed with type 2 diabetes were treated with Metformin Hydrochloride Tablets 1 — 2 g/d for at least three months, the blood glucose control level and metabolic indicators were recorded, and the OCT1 and MATE1 genoty...更多

Objective To investigate the effect of organic cation transporter 1 and multidrug and toxin efflux transporter 1 gene polymorphisms on blood glucose indicators in type 2 diabetes patients treated with metformin. Methods Using the cross-sectional study method, all participants diagnosed with type 2 diabetes were treated with Metformin Hydrochloride Tablets 1 — 2 g/d for at least three months, the blood glucose control level and metabolic indicators were recorded, and the OCT1 and MATE1 genotypes were determined. Statistical analyses were performed using IBM SPSS Statistics for Windows V22.0 to analyze the correlation between different genotypes and patients' blood glucose levels and metabolic indicators. Results A total of 191 patients with type 2 diabetes were included. The fasting blood glucose level of MATE1 AA/AG genotype carriers was significantly lower than that of GG genotype patients, but the high-density lipoprotein cholesterol level was significantly higher than that of GG genotype patients. The logistics regression results showed that MATE1 had statistical significance for FPG, body mass index , and HDL-C. The interaction model analysis showed that patients with both OCT1 AA and MATE1 GG genes in FPG exhibited significant interaction and synergistic effects, with no significant multiplicative effects. Conclusion The polymorphism of OCT1 and MATE1 genes is significantly associated with the blood glucose of type 2 diabetes patients treated with metformin. There is a synergistic effect in the correlation with FPG, and it is also associated with lipid metabolism and BMI levels. The polymorphism of OCT1 and MATE1 genes may have a predictive role in the blood glucose and metabolic indicators of type 2 diabetes patients treated with metformin.收起

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