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作者

Xin Chen, Jialing Wang, Tingting Deng, Qing Ni, Fanjie Liu

作者单位

Affiliations ¹ Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. ² College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. ³ Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ⁴ Bone Biomechanics Engineering Laboratory of Shandong Province, Shandong Medicinal Biotechnology Center (School of Biomedical Sciences), Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

刊名

Journal of bone metabolism

年份

2025

卷号

Vol.32 No.4

页码

247-262

ISSN

2287-6375

关键词

Bone and Bones Brain Hypothalamus Neurosecretory systems Osteoporosis.

摘要

Osteoporosis is a systemic skeletal disease characterized by reduced bone mass and increased risk of fractures, with limitations in traditional treatment methods. The 'brainbone axis' theory has revealed a bidirectional regulatory network between the central nervous system and the skeletal system, providing new insights into the mechanisms and treatment of OP. This review summarizes the bidirectional regulatory mechanisms of the 'brain-bone axis', including descending pathways and ascending fe...更多

Osteoporosis is a systemic skeletal disease characterized by reduced bone mass and increased risk of fractures, with limitations in traditional treatment methods. The 'brainbone axis' theory has revealed a bidirectional regulatory network between the central nervous system and the skeletal system, providing new insights into the mechanisms and treatment of OP. This review summarizes the bidirectional regulatory mechanisms of the 'brain-bone axis', including descending pathways and ascending feedback , and explores the synergistic roles of endocrine systems within this network. Additionally, the article summarizes multi-modal treatment strategies based on the 'brain-bone axis' theory, offering new insights for the precise prevention and treatment of OP. Future research should further integrate basic and clinical studies to advance the paradigm shift of OP from a localized bone disorder to a systemic disease.收起

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