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作者

Xingjie Li Chumeng Zhang Shanshan Zhao Xiao Chang Hua Tang

作者单位

⁴Department of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, Sichuan, China ⁵College of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China ³School of Clinical and Basic Medicine, Shandong First Medical University, Jinan, Shandong, China ¹Shandong Provincial Lab for Clinical Immunology Translational Medicine in Universities, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China ⁶Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China ²Institute of Infection and Immunity, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China

刊名

Frontiers in Immunology

年份

2026

卷号

Vol.17

关键词

asthma CD36 immunometabolic checkpoint PPAR-γ type 2 inflammation

摘要

Asthma arises from complex interactions between genetic susceptibility and environmental exposure, yet the molecular pathways linking these processes remain incompletely understood. Recent human genetic studies have implicated CD36, a multifunctional class B scavenger receptor, in asthma risk, renewing interest in its immunological functions beyond lipid transport. Accumulating evidence suggests that CD36 influences multiple stages of disease pathogenesis, including allergen recognition and upta...更多

Asthma arises from complex interactions between genetic susceptibility and environmental exposure, yet the molecular pathways linking these processes remain incompletely understood. Recent human genetic studies have implicated CD36, a multifunctional class B scavenger receptor, in asthma risk, renewing interest in its immunological functions beyond lipid transport. Accumulating evidence suggests that CD36 influences multiple stages of disease pathogenesis, including allergen recognition and uptake, immune-cell activation and lipid-dependent metabolic adaptation. The identification of the asthma-protective variant rs75326924 has further connected CD36 biology to human disease and provided a genetic framework for mechanistic investigation. At the same time, emerging studies suggest that CD36 integrates extracellular lipid cues with intracellular immunometabolic programs that support persistent inflammatory responses, thereby providing a potential mechanistic link between environmental exposure and disease susceptibility. In this review, we discuss current evidence linking CD36 to asthma susceptibility and pathogenesis, evaluate the mechanistic basis of its immunological activities and discuss its potential as a biomarker and therapeutic target. We propose that CD36 represents a candidate immunometabolic checkpoint at the intersection of environmental sensing, metabolic regulation and genetic risk.收起

文献类型

期刊