获取途径

作者

Yunjing Zhang Kai Wang Wei Qin Cheng Jin Yiqing Song Peng Jia Shengfeng Wang Yongfeng Song Yi Ning Liming Li

作者单位

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China Department of Social Medicine and Health Education, School of Public Health, PKUHSC, Beijing, China Meinian Institute of Health, Beijing, China PKUHSC Meinian Public Health Research Institute, Beijing, China Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, United States School of Resources and Environmental Science, Wuhan University, Wuhan, China 0International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China Meinian Institute of Health, Beijing, China PKUHSC Meinian Public Health Research Institute, Beijing, China Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China

刊名

Frontiers in Endocrinology

年份

2021

卷号

Vol.12

ISSN

1664-2392

关键词

thyroid nodules PM2.5 PM10 NO2 SO2 CO

摘要

BackgroundThyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants and the risk of thyroid nodules.MethodsWe utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-specifi...更多

BackgroundThyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants and the risk of thyroid nodules.MethodsWe utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-specific concentrations of six pollutants from 2015 to 2017 were estimated based on the China’s National Urban Air Quality Real Time Publishing Platform. Thyroid nodule was measured with ultrasound. Multivariable Logistic regression was used to examine the associations between air pollutants and thyroid nodules with adjustment for age, sex, education, smoking, body mass index, fasting blood glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, urine iodine, gross domestic product, and thyroid stimulating hormone. We conducted stratified analyses to investigate potential effect modification by sex, age, and urine iodine groups.ResultsApproximately 38% of the participants were diagnosed with thyroid nodules. Each of the six air pollutants was significantly and linearly associated with the risk for thyroid nodules. The adjusted odds ratios [95% CI] for every increase of 10 μg/m3 for PM2.5, PM10, NO2, SO2, and O3 were 1.062 [1.061, 1.064], 1.04 [1.03, 1.04], 1.10 [1.09, 1.10], 1.11 [1.11, 1.12], and 1.151 [1.149, 1.154], respectively; The odds ratio for each increase of 1 mg/m3 for CO was 1.50 [1.49 to 1.52]. Furthermore, these associations were significantly higher in the participants who were men, younger, or having lower urine iodine level .ConclusionThe six air pollutants may contribute to the high prevalence of thyroid nodules in China.收起

文献类型

期刊

浏览量

2