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作者

Yunjing Zhang, Kai Wang, Wei Qin, Cheng Jin, Yiqing Song, Peng Jia, Shengfeng Wang, Yongfeng Song, Yi Ning, Liming Li

作者单位

Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. Department of Social Medicine and Health Education, School of Public Health, PKUHSC, Beijing, China. Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China. PKUHSC Meinian Public Health Research Institute, Beijing, China. Meinian Institute of Health, Beijing, China. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center (PKUHSC), Beijing, China. Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, United States. Affiliations Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China. School of Resources and Environmental Science, Wuhan University, Wuhan, China. 10 International Institute of Spatial Lifecourse Epidemiology (ISLE), Wuhan University, Wuhan, China.

刊名

Frontiers in endocrinology

年份

2021

卷号

Vol.12

页码

753607

ISSN

1664-2392

关键词

CO NO2 O3 PM10 PM2.5 SO2 dose–response relationship thyroid nodules.

摘要

Background: Thyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants and the risk of thyroid nodules. Methods: We utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-sp...更多

Background: Thyroid nodules has become a significant public health issue worldwide with a rapidly increasing prevalence. However, its association with outdoor air pollution remains poorly understood. We aim to investigate the relationship between six outdoor air pollutants and the risk of thyroid nodules. Methods: We utilized a database including 4,920,536 participants who attended the annual physical examinations in the Meinian HealthCare Screening Center in 157 Chinese cities in 2017. City-specific concentrations of six pollutants from 2015 to 2017 were estimated based on the China's National Urban Air Quality Real Time Publishing Platform. Thyroid nodule was measured with ultrasound. Multivariable Logistic regression was used to examine the associations between air pollutants and thyroid nodules with adjustment for age, sex, education, smoking, body mass index, fasting blood glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, urine iodine, gross domestic product, and thyroid stimulating hormone. We conducted stratified analyses to investigate potential effect modification by sex, age, and urine iodine groups. Results: Approximately 38% of the participants were diagnosed with thyroid nodules. Each of the six air pollutants was significantly and linearly associated with the risk for thyroid nodules. The adjusted odds ratios [95% CI] for every increase of 10 μg/m 3 for PM 2.5 , PM 10 , NO 2 , SO 2 , and O 3 were 1.062 [1.061, 1.064], 1.04 [1.03, 1.04], 1.10 [1.09, 1.10], 1.11 [1.11, 1.12], and 1.151 [1.149, 1.154], respectively; The odds ratio for each increase of 1 mg/m 3 for CO was 1.50 [1.49 to 1.52]. Furthermore, these associations were significantly higher in the participants who were men, younger, or having lower urine iodine level . Conclusion: The six air pollutants may contribute to the high prevalence of thyroid nodules in China.收起

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