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作者

Libo Liu, Qian Shi, Xiaohong Liu, Yanmin Li, Xiuchang Li

作者单位

Department of Cardiology, People's Hospital of Mudan, Heze, Shandong, PR China. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, PR China. Affiliations

刊名

American journal of hypertension

年份

2022

卷号

Vol.35 No.2

页码

156-163

ISSN

1941-7225

关键词

blood pressure hydrogen hypertension myocardial fibrosis oxidative stress pirfenidone.

摘要

Background: Previous studies have shown that hydrogen can antagonize the fibrosis of various organs. We investigated whether hydrogen-rich saline can attenuate myocardial fibrosis in spontaneously hypertensive rats and clarified the mechanisms involved. Methods: We examined the effect of HRS and pirfenidone on myocardial fibrosis in SHR. Systolic blood pressure, left ventricular mass index , and heart weight index were measured, Masson trichrome staining was performed. We assessed the role o...更多

Background: Previous studies have shown that hydrogen can antagonize the fibrosis of various organs. We investigated whether hydrogen-rich saline can attenuate myocardial fibrosis in spontaneously hypertensive rats and clarified the mechanisms involved. Methods: We examined the effect of HRS and pirfenidone on myocardial fibrosis in SHR. Systolic blood pressure, left ventricular mass index , and heart weight index were measured, Masson trichrome staining was performed. We assessed the role of superoxide dismutase , malondialdehyde , Alpha-smooth muscle actin , collagen I, collagen III, and tissue inhibitors of metalloproteinases in myocardium. We detected the concentrations of procollagen type-I C-terminal propeptide , procollagen type-III N-terminal propeptide , and angiotensin II in rat serum. Furthermore, the relative protein levels of the transforming growth factor beta /Smad pathway were tested. Results: We discovered that HRS decreases LVMI . PFD had similar effect compared with HRS and control group. Conclusions: HRS reduced oxidative stress and improved myocardial collagen content, which may be related to inhibition of the TGF-β signaling pathway. This suggests that HRS is an effective therapeutic strategy for myocardial fibrosis.收起

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