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作者单位

Department of Thoracic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China；Department of Thoracic Surgery，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan 250021，China

刊名

当代医学科学(英文)

年份

2024

卷号

第44卷

期号

第2期

页码

309-327

关键词

lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

摘要

Objective:Lung squamous cell carcinomais associated with a low survival rate.Evidence suggests that bone morphogenetic proteinsand their receptorsplay crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The'R/Limma'package was utilized to analyze the differential expression characteristics of BMPs/BMPRs i...更多

Objective:Lung squamous cell carcinomais associated with a low survival rate.Evidence suggests that bone morphogenetic proteinsand their receptorsplay crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The'R/Limma'package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO databases.Concurrently,the'survminer'packages were employed to investigate their prognostic value and correlation with clinical features in LUSC.The core gene associated with LUSC progression was further explored through weighted gene correlation network analysis.LASSO analysis was conducted to construct a prognostic risk model for LUSC.Clinical specimens wee examined by immunohistochemical analysis to confirm the diagnostic value in LUSC.Furthermore,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was explored.Results:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genesfor LUSC.GDF10 showed a significant positive correlation with immune cell infiltration and immune checkpoint expression.Conclusion:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.收起

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