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作者

Lin Yuan Yunqiu Wang Mengyuan Yu Zitong Feng Ming Ci Chunqing Wang Hanxiang Chen

作者单位

³Department of Radiation Oncology, the Third Hospital Affiliated with Shandong First Medical University, Jinan, Shandong, P.R. China ²These authors contributed equally ⁴Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China ⁵Lead contact ¹Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong, P.R. China

刊名

iScience

年份

2024

卷号

Vol.27 No.6

页码

110112

ISSN

2589-0042

摘要

The impact of endothelial cell-specific molecule 1 on the initiation and progression of diverse cancers has been extensively studied, yet its regulatory mechanisms in relation to cervical cancer remain insufficiently understood. Through bioinformatics analysis, we revealed that ESM1 was highly expressed in cervical squamous cell carcinoma and endocervical adenocarcinoma and correlated with dismal clinicopathological features. The activation of ESM1 is facilitated by the presence of oncogenic H...更多

The impact of endothelial cell-specific molecule 1 on the initiation and progression of diverse cancers has been extensively studied, yet its regulatory mechanisms in relation to cervical cancer remain insufficiently understood. Through bioinformatics analysis, we revealed that ESM1 was highly expressed in cervical squamous cell carcinoma and endocervical adenocarcinoma and correlated with dismal clinicopathological features. The activation of ESM1 is facilitated by the presence of oncogenic HPV E6 and E7. HPV E6 and E7 enhance the expression of ESM1 by diminishing the levels of miR-205-5p, which specifically targets the 3′ untranslated region of ESM1 mRNA. In addition, we demonstrated that ESM1 facilitates aerobic glycolysis of cervical cancer cells via the Akt/mTOR pathway. Suppression of ESM1 led to a reduction in the expression of HIF-1α and multiple glycolytic enzymes. Taken together, our findings provide insights into the mechanisms by which HPV infections regulate oncogenes, thereby contributing to cervical carcinogenesis.收起

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