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作者

Yingnan Liu Shuping Cheng Taotao Dong Chao Jiang Jinming Yu Linlin Wang

作者单位

¹Shandong University Cancer Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250117, China ³These authors contributed equally ⁶Lead contact ⁵Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China ⁴Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, Shandong 250063, China ²Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, Jinan 250117, China

刊名

iScience

年份

2025

卷号

Vol.28 No.12

页码

114188

关键词

Oncology Therapeutics

摘要

This study aimed to define optimal treatment strategies for metastatic esophageal cancer with different progressive patterns after first-line immunotherapy resistance. Patients were stratified into oligoprogression and polyprogression, with further subclassifications . Oligoprogression patients receiving radiotherapy had longer progression-free survival and overall survival , especially in the REO subgroup . Polyprogression patients on IO rechallenge showed improved PFS and OS , particular...更多

This study aimed to define optimal treatment strategies for metastatic esophageal cancer with different progressive patterns after first-line immunotherapy resistance. Patients were stratified into oligoprogression and polyprogression, with further subclassifications . Oligoprogression patients receiving radiotherapy had longer progression-free survival and overall survival , especially in the REO subgroup . Polyprogression patients on IO rechallenge showed improved PFS and OS , particularly in the REP subgroup . Overall, RT is more important for patients with REO, while IO rechallenge could play a more dominant role for REP.收起

文献类型

期刊