Maximizing survival benefit with precision therapy based on progressive patterns after immunochemotherapy in metastatic esophageal cancer

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作者单位: ¹Shandong University Cancer Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250117, China ³These authors contributed equally ⁶Lead contact ⁵Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China ⁴Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, Shandong 250063, China ²Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, Jinan 250117, China

摘要: This study aimed to define optimal treatment strategies for metastatic esophageal cancer with different progressive patterns after first-line immunotherapy resistance. Patients were stratified into oligoprogression and polyprogression, with further subclassifications . Oligoprogression patients receiving radiotherapy had longer progression-free survival and overall survival , especially in the REO subgroup . Polyprogression patients on IO rechallenge showed improved PFS and OS , particular...更多; This study aimed to define optimal treatment strategies for metastatic esophageal cancer with different progressive patterns after first-line immunotherapy resistance. Patients were stratified into oligoprogression and polyprogression, with further subclassifications . Oligoprogression patients receiving radiotherapy had longer progression-free survival and overall survival , especially in the REO subgroup . Polyprogression patients on IO rechallenge showed improved PFS and OS , particularly in the REP subgroup . Overall, RT is more important for patients with REO, while IO rechallenge could play a more dominant role for REP.收起

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