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作者

Yang Yao Tiantian Shan Xiaoying Li

作者单位

⁴Department of Emergency, Jinan Central Hospital, Jinan 250013, China ¹Department of Anesthesiology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266011, China ³Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China ²Research Center of Translational Medicine, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, China ⁶Lead contact ⁵Department of Emergency, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, China

刊名

iScience

年份

2024

卷号

Vol.27 No.12

页码

111354

ISSN

2589-0042

摘要

Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis. In this study, we utilized blood vessel organoids to investigate the impact...更多

Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis. In this study, we utilized blood vessel organoids to investigate the impact of high glucose on vasculogenesis and subsequent angiogenesis. We found that BVOs in the vascular lineage induction stage were more sensitive to high glucose and more susceptible to affect endothelial cell differentiation and function. Moreover, hucMSCs can alleviate the high glucose-induced inhibition of endothelial cell differentiation and dysfunction through MAPK signaling pathway downregulation, with the MAPK activator dimethyl fumarate further illustrating the results. Thereby, we demonstrated that high glucose can lead to abnormal vasculogenesis and impact subsequent angiogenesis, and hucMSCs can alleviate this effect.收起

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