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作者

Chunyan Luo, Jingyang Zhang, Xiaorao Wang, Yu Dai, Lei Yan, Yanbo Du

作者单位

com. ²⁴ Reproductive Hospital Affiliated to Shandong University, No.157, Jingliu Road, Shizhong District, Jinan, 250012, Shandong, China. duyanboivf@16 com. ²³ Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, 250012, Shandong, China. duyanboivf@16 com. ²⁰ Shandong Technology Innovation Center for Reproductive Health, Jinan, 250012, Shandong, China. duyanboivf@16 com. ²² Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China. duyanboivf@16 com. ¹⁹ Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, Shandong, China. duyanboivf@16 com. ¹⁸ National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, Shandong, China. duyanboivf@16 Affiliations ¹ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. ² National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, Shandong, China. ³ Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, Shandong, China. ⁴ Shandong Technology Innovation Center for Reproductive Health, Jinan, 250012, Shandong, China. ⁵ Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, 250012, Shandong, China. ⁶ Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China. ⁷ Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, 250012, Shandong, China. ⁸ Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China. ⁹ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. yanlei@sdu.edu.cn. ¹⁰ National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹¹ Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹² Shandong Technology Innovation Center for Reproductive Health, Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹³ Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹⁴ Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250012, China. yanlei@sdu.edu.cn. ¹⁵ Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹⁶ Reproductive Hospital Affiliated to Shandong University, No.157, Jingliu Road, Shizhong District, Jinan, 250012, Shandong, China. yanlei@sdu.edu.cn. ¹⁷ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. duyanboivf@16 com. com. ²¹ Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, 250012, Shandong, China. duyanboivf@16

刊名

Reproductive sciences (Thousand Oaks, Calif.)

年份

2024

ISSN

1933-7205

关键词

Embryo cryopreservation In vitro oocyte maturation Premature ovulation Window of implantation.

摘要

There is limited clinical research investigating the optimal transplantation strategy in early oocyte retrieval cycles. We aimed to assess whether the maturation of oocytes from early oocyte retrieval influenced pregnancy outcomes, and to find the optimal embryo transfer strategy for patients who had early oocyte retrieval and underwent in vitro maturation . A retrospective cohort study was conducted in a university-based reproductive medical center. A total of 234 women who underwent single em...更多

There is limited clinical research investigating the optimal transplantation strategy in early oocyte retrieval cycles. We aimed to assess whether the maturation of oocytes from early oocyte retrieval influenced pregnancy outcomes, and to find the optimal embryo transfer strategy for patients who had early oocyte retrieval and underwent in vitro maturation . A retrospective cohort study was conducted in a university-based reproductive medical center. A total of 234 women who underwent single embryo transfer after early oocyte retrieval were included. The primary outcome was live birth rate. The live birth rate was significantly lower in IVM cycles compared with no IVM cycles. There was a significant decrease in live birth and a markedly elevated early pregnancy loss rate for IVM fresh cycles compared with no IVM fresh cycles. However, these findings were not repeated in subgroup analysis when frozen-thaw embryos were transferred. These results indicate that patients who underwent early oocyte retrieval and then IVM-intracytoplasmic sperm injection should be recommended the embryo cryopreservation strategy. Resynchronization of the embryo and the endometrium in frozen-thaw embryo transfer cycles may optimize live birth and decrease early pregnancy loss in IVM-intracytoplasmic sperm injection cycles after early oocyte retrieval.收起

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