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作者

Ziyang Wang, Lingjun Zhou, Fei Wang, Xiaochen Jiang, Weifeng Wang, Xueling Qiu, Yihui Xing, Chongjian Fu, Ping Zhong, Lu Tang

作者单位

Affiliations ¹ Department of Stomatology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, Shandong, 250031, China School of Nursing, Shandong First Medical University, Taian, 271016, China. ⁵ Department of Outpatient Comprehensive Management, Qingdao Stomatological Hospital, Qingdao, 266001, China. ⁶ Department of Stomatology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, Shandong, 250031, China. ⁷ Department of rehabilitation medicine, The 960th Hospital of People' s Liberation Army of China (PLA), Jinan, 250031, China. ⁸ Department of Stomatology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, Shandong, 250031, China. Electronic address: tanglu_office@16 School of Nursing, Shandong Second Medical University, Weifang, Shandong, 261053, China. ² School of Nursing, Naval Military Medical University, Shanghai, 571623, China. ³ Department of Anesthesiology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, Shandong, 250031, China. ⁴ Department of Stomatology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, Shandong, 250031, China com.

刊名

Annals of physical and rehabilitation medicine

年份

2025

卷号

Vol.68 No.2

页码

101897

ISSN

1877-0665

关键词

Anesthesia Anterior cruciate ligament reconstruction Nitrous oxide Rehabilitation.

摘要

Background: Although there is increasing emphasis on rehabilitation training after ligament reconstruction, little is known about the pain induced by the procedure itself. Procedural success may be limited by pain and anxiety. Nitrous oxide is widely used to alleviate procedural pain. However, few studies have been conducted to show the efficacy and safety of nitrous oxide for rehabilitation training. Objectives: To explore the short-term efficacy and safety of nitrous oxide for acute pain elici...更多

Background: Although there is increasing emphasis on rehabilitation training after ligament reconstruction, little is known about the pain induced by the procedure itself. Procedural success may be limited by pain and anxiety. Nitrous oxide is widely used to alleviate procedural pain. However, few studies have been conducted to show the efficacy and safety of nitrous oxide for rehabilitation training. Objectives: To explore the short-term efficacy and safety of nitrous oxide for acute pain elicited by rehabilitation training. Methods: A double-blinded randomized placebo-controlled trial was conducted in the department of rehabilitation medicine. People willing to participate in the trial and sign informed consent, ≥18 years old, who had acute pain caused by rehabilitation training after anterior cruciate ligament reconstruction were recruited. Participants undergoing rehabilitation training were randomized to receive either 65 % nitrous oxide or 100 % oxygen. The primary outcome was the pain score. Secondary outcomes were sedation score, range of motion, vital signs, physician and participant satisfaction, acceptance, and side effects. Results: 120 people were enrolled; 60 received nitrous oxide and 60 received oxygen. The nitrous oxide group had a significantly lower pain score than the placebo group and sedation scores during the procedure. Both physician and participant satisfaction were significantly higher in the intervention group than the placebo group. Acceptance differed between groups . No serious side effects occurred. Conclusion: This study provides evidence supporting the efficacy and safety of self-administered nitrous oxide to reduce procedural pain during rehabilitation training after anterior cruciate ligament reconstruction.收起

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