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作者

Kexin Meng Xinzhuo Tu Feixia Sun Lingmi Hou Zhouxiang Shao Jinxiang Wang

作者单位

⁷Breast Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China ⁴Authors contributed equally to this work. ⁹Precision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China ⁸Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China ⁵Department of Pathology, Air Force Medical Center, PLA, Beijing, China ⁶Nursing Department, Shandong First Medical University Affiliated Occupational Disease Hospital (Shandong Provincial Occupational Disease Hospital), Jinan, China ²Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang 310014, China ³Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China ¹Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China

刊名

International Journal of Biological Macromolecules

年份

2025

页码

140441

ISSN

0141-8130

摘要

The use of natural products for cancer treatment has a lengthy history. The safety and multifunctionality of naturally occurring substances have rendered them appropriate for cancer treatment. Curcumin influences multiple molecular pathways and is advantageous for treating both hematological and solid tumors. Nonetheless, the effectiveness of curcumin in vivo and in clinical studies has faced scrutiny due to its inadequate pharmacokinetic profile. Consequently, nanoparticles have been created fo...更多

The use of natural products for cancer treatment has a lengthy history. The safety and multifunctionality of naturally occurring substances have rendered them appropriate for cancer treatment. Curcumin influences multiple molecular pathways and is advantageous for treating both hematological and solid tumors. Nonetheless, the effectiveness of curcumin in vivo and in clinical studies has faced scrutiny due to its inadequate pharmacokinetic profile. Consequently, nanoparticles have been created for the administration of curcumin in cancer treatment. The nanoparticles can enhance the distribution of curcumin in tissues and increase its therapeutic effectiveness. Furthermore, nanoparticles expand the uptake of curcumin in cancer cells, leading to heightened cytotoxicity. Carbohydrate nanoparticles provide a promising solution for delivering curcumin in cancer treatment by tackling its low solubility, limited bioavailability, and quick degradation. These biodegradable and biocompatible carriers, originating from polymers such as chitosan, hyaluronic acid, and alginate, safeguard curcumin, improving its stability and allowing for controlled release. Targeting ligands for functionalization guarantee selective distribution to tumor cells, enhancing therapeutic effectiveness and reducing off-target impacts. Their capacity to encapsulate curcumin with other agents allows for synergistic therapies, enhancing anticancer results even more. The adjustable characteristics of carbohydrate nanoparticles, along with their minimal toxicity, create a revolutionary platform.收起

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