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作者

Yulu Song James J. Prisciandaro Dace Apšvalka Mae Bernard Adam Berrington Miguel Castelo-Branco Mark K. Britton Marta M. Correia Koen Cuypers Aleksandra Domagalik Ulrike Dydak Niall W. Duncan Gerard E. Dwyer Tao Gong Ian Greenhouse Katarzyna Hat Melina Hehl Shiori Honda Chris Horton Steve C.N. Hui

作者单位

³³Consciousness Lab, Institute of Psychology, Jagiellonian University, Kraków, Poland ⁴Ewha Brain Institute, Graduate School of Pharmaceutical Sciences, and Dept. of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea ²⁸Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA ³⁴Translational MRI, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium ¹⁷Center for Cognitive Aging and Memory and McKnight Brain Institute, University of Florida, Gainesville, FL, USA ²⁵Brain and Consciousness Research Centre, TMU Shuang-Ho Hospital, New Taipei City, Taiwan ⁸Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK ²³Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA 7XH, UK ³¹Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA ¹⁰Neurotherapeutics Ltd, The Ingenuity Centre, University of Nottingham Innovation Park, Triumph Road, Nottingham N ²²School of Health Sciences, Purdue University, West Lafayette, IN, USA ⁵School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK ²⁷NORMENT Centre of Excellence, Haukeland University Hospital, Bergen, Norway ⁹Multimodal Imaging Group, Centre for Addiction and Mental Health, University of Toronto, Canada ⁷Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 4796, USA ¹³MRC Cognition and Brain Sciences Unit, University of Cambridge, UK ²⁹Departments of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Jinan, Shandong, China ¹⁵Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK ²⁴Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan ³²Doctoral School in the Social Sciences, Jagiellonian University, Poland ⁶School of Psychology, University of Surrey, Guildford G ¹⁴School of Psychology and Sports Sciences, Bangor University, Bangor, UK ¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ³⁶Developing Brain Institute, Children’s National Hospital, Washington, DC, USA ²¹Centre for Brain Research, Jagiellonian University, Krakow, Poland ³School of psychology, University of Nottingham, Nottingham, UK ²⁶Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway ¹¹Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL 32611, USA 2TU, UK ¹⁹Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium ³⁷Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA ²⁰Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium ³⁰Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA ¹²Addiction Sciences Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA ³⁸Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA ³⁵Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan ¹⁸Neuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium ¹⁶Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Portugal

刊名

Journal of Neuroscience Methods

年份

2025

卷号

Vol.418

页码

110430

ISSN

0165-0270

关键词

Gamma-aminobutyric acid (GABA) Glutathione (GSH) Magnetic resonance, spectroscopy (MRS) Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES) Menstrual cycle Oestrogen

摘要

Background Gamma-aminobutyric acid and glutathione play a significant role in the functioning of a healthy brain and can both be quantified using magnetic resonance spectroscopy . Several small-scale studies have suggested MRS measured GABA may fluctuate with the menstrual cycle, but the effects on GSH are unknown. Utilising recent developments in MRS acquisition, this multi-lab study explores this issue across 4 distinctive brain regions. New methods Data were analysed from 12 independent sit...更多

Background Gamma-aminobutyric acid and glutathione play a significant role in the functioning of a healthy brain and can both be quantified using magnetic resonance spectroscopy . Several small-scale studies have suggested MRS measured GABA may fluctuate with the menstrual cycle, but the effects on GSH are unknown. Utilising recent developments in MRS acquisition, this multi-lab study explores this issue across 4 distinctive brain regions. New methods Data were analysed from 12 independent sites from which a total of 30 women were scanned during three phases of their menstrual cycle corresponding to early follicular, ovulation and mid luteal phases. HERMES and HERCULES sequences were used to measure GABA and GSH in voxels located in the left motor cortex, left posterior insular, medial parietal and medial frontal. Linear mixed models were used to assess the variability contributed by site, participant and menstrual cycle phase. Results Similar variance was attributed to site and menstrual cycle phase for both GABA and GSH data. No systematic changes in GABA or GSH were revealed for any voxel as a consequence of menstrual cycle phase. Comparison with existing methods Despite our larger sample size and inclusion of more brain regions we fail to replicate previous findings of GABA change as a consequence of menstrual cycle phase. We also show for the first time that MRS measures of GSH so not significantly alter with cycle. Conclusions Our findings suggest that the menstrual cycle has minimal impact on MRS measures of GABA and GSH. The presence of a menstrual cycle should not be used as justification for exclusion of women in MRS studies.收起

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