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作者

Qiqi Yang Xiang Zhao Lemey, Philippe Suchard, Marc A. Yuhai Bi Weifeng Shi Di Liu Wenbao Qi Guogang Zhang Stenseth, Nils Chr. Pybus, Oliver G. Huaiyu Tian

作者单位

3PS Oxford, United Kingdom 15 Department of Pathobiology and Population Sciences, The Royal Veterinary College, A 7TA London, United Kingdom National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 102206 Beijing, China Department of Biostatistics, UCLA Fielding School of Public Health, University of California, Los Angeles, CA 90095 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, 100875 Beijing, China Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, 10010 Beijing, China Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, 518112 Shenzhen, China Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 Department of Microbiology, Immunology and Transplantation, Rega Institute, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium Institute of Pathogen Biology, Taishan Medical College, 271000 Taian, Shandong, China 10 Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071 Wuhan, Hubei, China 11 National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine, South China Agricultural University, 510642 Guangzhou, China 12 Research Institute of Forest Ecology, Environment and Protection, National Bird Banding Center of China, Chinese Academy of Forestry, Key Laboratory of Forest Protection of State Forestry and Grassland Administration, 100091 Beijing, China 13 Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, N-0316 Oslo, Norway 14 Department of Zoology, University of Oxford, O

刊名

Proceedings of the National Academy of Sciences of the United States of America

年份

2020

卷号

Vol.117 No.11

页码

5949-5954

ISSN

0027-8424

关键词

avian influenza community-structured transmission phylogeography poultry trade

摘要

The live poultry trade is thought to play an important role in the spread and maintenance of highly pathogenic avian influenza A viruses in Asia. Despite an abundance of small-scale observational studies, the role of the poultry trade in disseminating AIV over large geographic areas is still unclear, especially for developing countries with complex poultry production systems. Here we combine virus genomes and reconstructed poultry transportation data to measure and compare the spatial spread in...更多

The live poultry trade is thought to play an important role in the spread and maintenance of highly pathogenic avian influenza A viruses in Asia. Despite an abundance of small-scale observational studies, the role of the poultry trade in disseminating AIV over large geographic areas is still unclear, especially for developing countries with complex poultry production systems. Here we combine virus genomes and reconstructed poultry transportation data to measure and compare the spatial spread in China of three key subtypes of AIV: H5N1, H7N9, and H5N6. Although it is difficult to disentangle the contribution of confounding factors, such as bird migration and spatial distance, we find evidence that the dissemination of these subtypes among domestic poultry is geographically continuous and likely associated with the intensity of the live poultry trade in China. Using two independent data sources and network analysis methods, we report a regional-scale community structure in China that might explain the spread of AIV subtypes in the country. The identification of this structure has the potential to inform more targeted strategies for the prevention and control of AIV in China.收起

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