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作者

Zhuqing Li, Pinxin Si, Tingting Meng, Xiaoran Zhao, Chendi Zhu, Dunfang Zhang, Shutong Meng, Nianyu Li, Ran Liu, Tianxiang Ni, Junhao Yan, Hongchang Li, Ning Zhao, Chao Zhong, Yingying Qin, WanJun Chen, Zi-Jiang Chen, Xue Jiao

作者单位

Affiliations ¹ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China. ² National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China. ³ Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China. ⁴ Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China. ⁵ Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China. ⁶ Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China. ⁷ Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China. ⁸ Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. ⁹ Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ¹⁰ Analytical Biosciences Limited, Beijing 100191, China. ¹¹ Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-Related Diseases, Peking University, Beijing 100191, China. ¹² Mucosal Immunology Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. ¹³ Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China. ¹⁴ Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

刊名

Science immunology

年份

2025

卷号

Vol.10 No.106

页码

eado2463

ISSN

2470-9468

摘要

Regulatory T cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. T cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4 T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8 T cell subset specifically enriched in the...更多

Regulatory T cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. T cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4 T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8 T cell subset specifically enriched in the decidua . CCR8 dT cells were decreased in patients with recurrent pregnancy loss and an abortion-prone mouse model. Depletion of CCR8 dT cells increased susceptibility to fetal loss, with altered decidual immune profiles. Adoptive transfer of CCR8 T cells rescued fetal loss in abortion-prone mice. The CCR8 ligand CCL1 was mainly produced by decidual CD49a natural killer cells and was significantly decreased in patients with RPL. Our data demonstrate that CCR8 dT cells are required to maintain maternal-fetal tolerance and highlight potential avenues for RPL therapies.收起

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