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作者

Bowen Li, Yan Gao, Wenxian Wang, Runze Zhu, Xueqiao Yang, Huiyu Chen, Ximing Wang, Hui Gu

作者单位

Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China (B.L., Y.G., W.W., R.Z., X.Y., H.C., X.W., H.G.) School of Medical Imaging, Binzhou Medical University, No. 346 Guanhai Road, Yantai, Shandong 264003, PR China (W.W., X.Y.). ⁴ Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong 250117, China (B.L., R.Z., X.Y., H.C.) Department of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China (Y.G., X.Y., X.W.). ³ Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China (B.L., Y.G., W.W., R.Z., X.Y., H.C., X.W., H.G.) Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China (B.L., Y.G., W.W., R.Z., X.Y., H.C., X.W., H.G.). ² Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China (B.L., Y.G., W.W., R.Z., X.Y., H.C., X.W., H.G.) School of Medical Imaging, Binzhou Medical University, No. 346 Guanhai Road, Yantai, Shandong 264003, PR China (W.W., X.Y.). ⁵ Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China (B.L., Y.G., W.W., R.Z., X.Y., H.C., X.W., H.G.). Electronic address: hui_gu07@12 Department of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China (Y.G., X.Y., X.W.) com. Affiliations ¹ Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong 250117, China (B.L., R.Z., X.Y., H.C.)

刊名

Academic radiology

年份

2025

ISSN

1878-4046

关键词

Cardiac magnetic resonance imaging Hypertrophic cardiomyopathy Major adverse cardiac events Prognosis.

摘要

Rationale and objectives: Epicardial adipose tissue is thought to have a deleterious effect on the progression of myocardial disease; the extracellular volume fraction has been validated by histology to correlate with adverse myocardial remodeling. The aim of this study was to investigate the prognostic value of EAT volume index and ECV in patients with hypertrophic cardiomyopathy . Materials and methods: ECV and EAT were measured using cardiac magnetic resonance imaging in 201 subjects with...更多

Rationale and objectives: Epicardial adipose tissue is thought to have a deleterious effect on the progression of myocardial disease; the extracellular volume fraction has been validated by histology to correlate with adverse myocardial remodeling. The aim of this study was to investigate the prognostic value of EAT volume index and ECV in patients with hypertrophic cardiomyopathy . Materials and methods: ECV and EAT were measured using cardiac magnetic resonance imaging in 201 subjects with HCM. All patients were followed up prospectively. Major adverse cardiovascular events were categorized into primary and secondary endpoint events. The primary endpoint was a composite of cardiac death, heart transplant, and cardiopulmonary resuscitation following syncope. The secondary endpoint was defined as rehospitalization for heart failure . Results: After 26±16 months of follow-up, 43 patients experienced MACEs . Patients suffering from MACEs had significantly higher ECV and EATVI . After adjustment for body mass index , EATVI showed a significant correlation with ECV among HCM patients. In the Kaplan-Meier analysis, the incidence of MACE was significantly higher in patients with increased ECV and higher EATVI . In multivariate Cox regression analysis, ECV and EATVI were significantly associated with MACEs. Conclusion: In patients with HCM, ECV and EATVI measured by CMR are strong predictors of MACEs and improve risk stratification. Clinical implication: Extracellular volume fraction and epicardial adipose tissue are associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy and can improve their risk stratification.收起

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