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作者

Mei Ye, Dongxia Yan, Jie Xu, Dongqin Liu, Xiaoyan Liu, Wei Jiang, Ling Sha, Ke Long, Yi Feng, Shupeng Zhang, Jun Luo, Hong Xie, Rong Zou, Yuliang Deng, Jianxiang Geng, Jian Huang, Wanqiu Huang

作者单位

com. ¹⁰ The Cross-Strait Precision Medicine Association - HPV Infection Disease Professional Commitee, Nanjing, China. njgjx2022@16 Affiliations ¹ Jiangning District Maternal Child Health and Family Planning Service Center, Nanjing, Jiangsu, China. ² The Cross-Strait Precision Medicine Association - HPV Infection Disease Professional Commitee, Nanjing, China. ³ Department of Pathology, Maanshan People's Hospital, Maanshan, Anhui, China. ⁴ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. ⁵ Department of Pathology, Yancheng Maternity and Child Health care Hospital, Yancheng, Jiangsu, China. ⁶ Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China. ⁷ Reproductive Testing Quality Control, Department of Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu, China. ⁸ Department of gynecology, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, Shenzhen, Guangdong, China. ⁹ Department of Pathology, The Affiliated Nanjing Traditional Chinese Medical Hospital of Nanjing Traditional Chinese Medical University, Nanjing, Jiangsu, China. njgjx2022@16 com. ¹¹ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. jianhuang@sjtu.edu.cn. ¹² The Cross-Strait Precision Medicine Association - HPV Infection Disease Professional Commitee, Nanjing, China. jianhuang@sjtu.edu.cn. ¹³ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. wqhuang@sjtu.edu.cn.

刊名

Virology journal

年份

2025

卷号

Vol.22 No.1

页码

323

ISSN

1743-422X

关键词

Adenocarcinoma Age-specific prevalence Cervical cancer screening China HPV genotypes HPV-related anxiety Human papillomavirus Squamous cell carcinoma.

摘要

Background: Persistent infection with high-risk human papillomavirus is the primary cause of cervical cancer. Understanding genotype distribution and evaluating screening strategies are essential for effective prevention. Methods: We retrospectively analyzed cervical cancer screening data from 97,686 women aged 35-64 years in Nanjing . Among these, 30,147 underwent combined cytology and HPV testing and 67,539 TCT alone. HPV genotyping was further performed in 3,362 histologically confirmed cerv...更多

Background: Persistent infection with high-risk human papillomavirus is the primary cause of cervical cancer. Understanding genotype distribution and evaluating screening strategies are essential for effective prevention. Methods: We retrospectively analyzed cervical cancer screening data from 97,686 women aged 35-64 years in Nanjing . Among these, 30,147 underwent combined cytology and HPV testing and 67,539 TCT alone. HPV genotyping was further performed in 3,362 histologically confirmed cervical cancer cases from multiple regions in China. Results: Combined screening achieved a significantly higher detection rate of abnormalities than TCT alone . Overall HPV positivity was 11.19%, increasing with age and peaking at 16.85% in women aged 60-64. The most frequent genotypes were HPV52, HPV58, and HPV16. In cervical cancer cases, HPV was detected in 92.73% of SCC and 59.77% of ADC. The proportion of HPV-negative cancers increased with age, particularly in ADC. Conclusions: Combined TCT and HPV testing improves detection of cervical lesions compared with cytology alone. The observed age-specific and histology-specific differences in HPV prevalence and genotype distribution emphasize the need for tailored screening strategies, particularly for older women. These findings provide region-specific evidence to support the refinement of cervical cancer prevention and control strategies in China, particularly in contexts with similar demographic and epidemiological characteristics to the study population.收起

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