Advances in drug research targeting ubiquitin-specific protease 7

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作者单位: ^bShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264117, China ^aShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China

关键词: cancer therapy deubiquitinase inhibitor ubiquitin-proteasome system ubiquitin-specific protease 7

摘要: Ubiquitin-specific protease 7 is one of the more widely studied members of the deubiquitinating enzyme family, which regulates the activity and function of a variety of proteins in cells. USP7 is closely associated with the tumor progression, which makes USP7 a highly promising target for drug therapy. However, no drug targeting USP7 has yet been approved for clinical trials, thus the development of drug targeting USP7 still requires in-depth research. This article reviews the structure and fun...更多; Ubiquitin-specific protease 7 is one of the more widely studied members of the deubiquitinating enzyme family, which regulates the activity and function of a variety of proteins in cells. USP7 is closely associated with the tumor progression, which makes USP7 a highly promising target for drug therapy. However, no drug targeting USP7 has yet been approved for clinical trials, thus the development of drug targeting USP7 still requires in-depth research. This article reviews the structure and function of USP7 and the progress of drug research targeting USP7.收起

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