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作者

杜西顺 修 鹏

作者单位

济宁医学院临床医学院(附属医院)肝胆外科，山东 济宁 山东第一医科大学第一附属医院(山东省千佛山医院)肝胆外科，山东 济南

刊名

Advances in Clinical Medicine

年份

2026

卷号

Vol.16 No.1

页码

2381-2386

ISSN

2161-8712

关键词

肝肉瘤样癌 手术切除 胆管细胞癌 病例报告 Hepatic Sarcomatoid Carcinoma Surgical Resection Cholangiocarcinoma Case Report

摘要

Hepatic Sarcomatoid Carcinoma is an extremely rare and highly malignant primary hepatic tumor, accounting for approximately 2% of resected liver specimens. Its pathogenesis has not been fully elucidated, and current evidence suggests that it may be closely associated with epithelial-mesenchymal transition . The core pathological feature of this tumor is the coexistence of epithelial-derived carcinomatous components and metaplastic mesenchymal-derived sarcomatoid components within the same lesi...更多

Hepatic Sarcomatoid Carcinoma is an extremely rare and highly malignant primary hepatic tumor, accounting for approximately 2% of resected liver specimens. Its pathogenesis has not been fully elucidated, and current evidence suggests that it may be closely associated with epithelial-mesenchymal transition . The core pathological feature of this tumor is the coexistence of epithelial-derived carcinomatous components and metaplastic mesenchymal-derived sarcomatoid components within the same lesion, with transitional morphologies often observed between the two, forming a typical biphasic histological pattern. Due to the extremely low incidence of HSC, its clinical manifestations are non-specific, and the features of laboratory examinations and imaging findings are mostly similar to those of common primary liver cancer, resulting in great difficulty in preoperative diagnosis and a high risk of misdiagnosis as conventional hepatocellular carcinoma, cholangiocarcinoma, or metastatic tumors. A definitive diagnosis still relies on postoperative histopathological examination combined with immunohistochemical analysis. This paper reports a case of HSC confirmed by surgical resection and pathological examination, systematically reviews its clinical data, imaging manifestations, pathological features, and treatment process, and conducts a comprehensive analysis by integrating relevant domestic and international literature. The aim is to deepen the understanding of this disease among clinicians and radiologists, improve the rate of early diagnosis, explore reasonable treatment strategies, and enhance patient prognosis.收起

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