Research Advances on Novel Biomarkers for Diagnosis and Prognosis of Abdominal Aortic Aneurysms

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关键词: 腹主动脉瘤生物标志物炎症诊断 Abdominal Aortic Aneurysm Biomarkers Inflammation Diagnosis

摘要: Abdominal aortic aneurysm is a fatal vascular disease with a stealthy onset and high mortality upon rupture, which is closely associated with a variety of biomarkers. However, existing studies are still hampered by the drawbacks of low biomarker specificity and clinical utility. This review addresses the latest advancements in novel AAA biomarkers, classifying them into four main categories: inflammatory and immune markers, genetic and genomic markers, protein markers, and metabolic and circulat...更多; Abdominal aortic aneurysm is a fatal vascular disease with a stealthy onset and high mortality upon rupture, which is closely associated with a variety of biomarkers. However, existing studies are still hampered by the drawbacks of low biomarker specificity and clinical utility. This review addresses the latest advancements in novel AAA biomarkers, classifying them into four main categories: inflammatory and immune markers, genetic and genomic markers, protein markers, and metabolic and circulating biomarkers. These markers have excellent potential to unravel AAA pathogenesis, diagnose early, predict aneurysm growth rate and rupture risk, and ascertain prognosis, thereby opening new avenues for future research.收起

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