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作者

王海舰 沈 彬

作者单位

山东第一医科大学第一附属医院(山东省千佛山医院)泌尿外科，山东 济南

刊名

Advances in Clinical Medicine

年份

2026

卷号

Vol.16 No.5

页码

1512-1520

ISSN

2161-8712

关键词

肾移植 侵袭性真菌病 宏基因组二代测序 诊断 治疗 Kidney Transplantation Invasive Fungal Disease Metagenomic Next-Generation Sequencing Diagnosis Treatment

摘要

Kidney transplantation serves as a core therapeutic approach for end-stage renal disease, which significantly improves patients’ quality of life. However, the postoperative immunosuppressive status renders recipients a high-risk population for invasive fungal disease . As a severe infectious complication after kidney transplantation, IFD is characterized by insidious onset, rapid disease progression and high mortality. Its early diagnosis and precise treatment are crucial for improving patients’...更多

Kidney transplantation serves as a core therapeutic approach for end-stage renal disease, which significantly improves patients’ quality of life. However, the postoperative immunosuppressive status renders recipients a high-risk population for invasive fungal disease . As a severe infectious complication after kidney transplantation, IFD is characterized by insidious onset, rapid disease progression and high mortality. Its early diagnosis and precise treatment are crucial for improving patients’ prognosis. The emergence of metagenomic next-generation sequencing technology has brought breakthroughs in the diagnosis of IFD, gradually transforming the traditional diagnosis and treatment model. This paper systematically reviews the research progress in the pathogenesis, clinical characteristics, diagnostic techniques and therapeutic strategies of IFD in kidney transplant recipients, with a focus on analyzing the application value of mNGS and traditional diagnostic methods, so as to provide references for clinically optimizing the diagnosis and treatment process of IFD and improving therapeutic effects.收起

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