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作者

Zi-Jian Wu Xin-Yue Zhao Yu-Hong Yang Cheng-Cheng Wang Yan Zheng Shi-Xiang Wu Cheng-Yu Yang Han-Ni Wei Qing-Yan Zou Yu-Ming Wang null Lei Du

作者单位

⁶Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China ⁴Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, Jinan, China ²Faculty of Health Sciences, University of Macau, Macau SAR, China ⁵SKL of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, China ¹Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China ³School of Food Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China

刊名

npj Science of Food

年份

2026

摘要

The global aging trend highlights the critical challenge of sarcopenia, which severely compromises both quality of life and overall survival time. This study aimed to investigate the effects of Antarctic krill oil on accelerated aging-induced skeletal muscle atrophy and its underlying mechanisms. An accelerated aging mouse model was established via daily intraperitoneal injection of 400 mg/kg D-galactose for 12 consecutive weeks. Concurrently, mice received oral gavage of KO or fish oil at 40...更多

The global aging trend highlights the critical challenge of sarcopenia, which severely compromises both quality of life and overall survival time. This study aimed to investigate the effects of Antarctic krill oil on accelerated aging-induced skeletal muscle atrophy and its underlying mechanisms. An accelerated aging mouse model was established via daily intraperitoneal injection of 400 mg/kg D-galactose for 12 consecutive weeks. Concurrently, mice received oral gavage of KO or fish oil at 400 mg/kg once daily. KO treatment mitigated D-gal-induced skeletal muscle atrophy and accelerated aging in mice, as evidenced by the attenuation of D-gal-induced declines in skeletal muscle mass, function, and muscle fiber cross-sectional area, as well as the downregulation of senescence markers. Notably, KO showed superior efficacy to FO. Moreover, KO treatment directly alleviated the D-gal-induced increase in senescence markers in C2C12 myotubes and mitigated the decrease in myotube diameter. Integrated transcriptomic and functional analyses identified AMP-activated protein kinase , a master regulator of mitochondrial homeostasis, as a key target of KO in preventing accelerated aging-induced skeletal muscle atrophy. Molecular docking simulations further suggested plausible direct interactions between major KO components and AMPK subunits. Critically, genetic silencing of AMPK abolished the protective effects of KO against D-gal-induced myotube atrophy, as KO failed to improve mitochondrial quality control dysfunction and protein homeostasis. Thus, AMPK is established as the central regulator mediating the anti-sarcopenic actions of KO. Overall, the present study demonstrates that KO is a promising nutraceutical for attenuating accelerated aging-induced skeletal muscle atrophy through an AMPK-dependent mechanism.收起

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