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作者

Zhang, Y Dang, S Wan, Y Yang, F Li, T

作者单位

Taishan Med Univ, Dept Gen Surg, Affiliated Hosp, Tai An, Shandong, Peoples R China Taishan Med Univ, Dept Intervent Radiol, Affiliated Hosp, 706 Taishan St, Tai An 271000, Shandong, Peoples R China Taishan Vocat Coll Nursing, Dept Basic Med, Tai An, Shandong, Peoples R China Taishan Med Univ, Dept Pathol, Affiliated Hosp, Tai An, Shandong, Peoples R China

刊名

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY

年份

2017

卷号

Vol.38 No.1

页码

45-48

ISSN

0392-2936

关键词

Breast cancer Molybdenum-targeted mammography VEGF COX-2 MMP-9

摘要

Aim: To investigate the correlation of the expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and matrix metalloprotease-9 (MMP-9) in breast cancer tissues with molybdenum-targeted X-ray images. Materials and Methods: Sixty-nine patients with invasive ductal carcinoma of the breast confirmed by molybdenum-targeted mammography, surgical, and pathologic examinations were enrolled. The expression of VEGF, COX-2, and MMP-9 were detected by immunohistochemical staining...更多

Aim: To investigate the correlation of the expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and matrix metalloprotease-9 (MMP-9) in breast cancer tissues with molybdenum-targeted X-ray images. Materials and Methods: Sixty-nine patients with invasive ductal carcinoma of the breast confirmed by molybdenum-targeted mammography, surgical, and pathologic examinations were enrolled. The expression of VEGF, COX-2, and MMP-9 were detected by immunohistochemical staining (IHS) and the correlation of VEGF, COX-2, and MMP-9 expression and classification of breast cancer on molybdenum-targeted X-ray was statistically analyzed. Results: The expression of VEGF, COX-2, and MMP-9 were significantly higher (p 0.05) between the group with (n = 30) and without (n = 39) calcification. Conclusion: Expression of VEGF, COX-2, and MMP-9 is highly correlated to the mammaographic appearance of spiculation, vascular abnormalities, and lymph node metastasis. However, the present results suggest that expression of VEGF, COX-2, and MMP-9 is either not or weakly correlated to mammographic appereance of calcification.收起

学科

【SCI学科】OBSTETRICS & GYNECOLOGY;ONCOLOGY 【ESI学科】CLINICAL MEDICINE

影响因子

2016年:0.692;2015年:0.58;2014年:0.611;2013年:0.602;2012年:0.577

文献类型

期刊

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