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作者

Adua, Eric Roberts, Peter Wang, Wei

作者单位

Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Clin Epidemiol, Beijing 100069, Peoples R China Taishan Med Univ, Sch Publ Hlth, Tai An 271000, Shandong, Peoples R China Edith Cowan Univ, Sch Med & Hlth Sci, 270 Joondalup Dr, Perth, WA 6027, Australia

刊名

EPMA JOURNAL

年份

2017

卷号

Vol.8 No.4

页码

345-355

ISSN

1878-5085

关键词

Chronic diseases Biomarkers Predictive Preventive and personalised medicine

摘要

Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status . We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people ...更多

Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status . We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016. The controls were categorised into high and low SHS based on how they rated on an SHS questionnaire-25 . Anthropometric and biochemical parameters: body mass index ; blood pressure ; fasting plasma glucose ; glycated haemoglobin ; serum lipids [, high- and low-density lipoprotein-cholesterol ] were measured. The male to female ratio for T2DM and controls were 99: 142 and 98: 166, respectively, whilst the mean ages were 55.89 and 51.52 years. Compared to controls, T2DM patients had higher FPG and HbA1c . Primarily sedentary [adjusted odds ratio = 2.97 ; p = 0.034)], systolic blood pressure and diastolic blood pressure significantly correlated with high SHS. After adjusting for age and gender, central adiposity [aOR = 1.74 ; p = 0.027)], underweight [aOR = 5.82 ; p = 0.018)], high SBP [aOR = 1.86 ; p = 0.012)], high DBP [aOR = 2.39 ; p = 0.001)] and high TG [aOR = 2.17 ; p = 0.029)] were found to be independent risk factors associated with high SHS. The management of T2DM in Ghana is suboptimal and undiagnosed risk factors remain prevalent. The SHSQ-25 can be translated and applied as a practical tool to screen at-risk individuals and hence prove useful for the purpose of predictive, preventive and personalised medicine.收起

学科

【SCI学科】MEDICINE, RESEARCH & EXPERIMENTAL 【ESI学科】CLINICAL MEDICINE

影响因子

2018年:4.661;2017年:3.9

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期刊

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3