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作者

杜世杰 刘成华

作者单位

山东第一医科大学(山东省医学科学院)研究生部，山东 济南 山东第一医科大学附属临沂市中心医院心血管内科，山东 临沂

刊名

Advances in Clinical Medicine

年份

2024

卷号

Vol.14 No.12

页码

1539-1544

ISSN

2161-8712

关键词

冠状动脉粥样硬化性心脏病 糖尿病 慢性炎症 白细胞介素-6 OX-2膜糖蛋白 Coronary Artery Atherosclerotic Heart Disease Diabetes Mellitus Chronic Inflammation Interleukin-6 CD200

摘要

Objective: To explore the regulatory effect of OX-2 membrane glycoprotein on chronic inflammation in patients with coronary heart disease complicated with diabetes mellitus . Methods: A total of 60 patients were enrolled in this study, including 20 patients with CHD, 20 patients with DM, and 20 patients with CHD complicated with DM, all of whom met the inclusion criteria. The concentration of CD200 molecules in the serum of each group was determined by ELISA, and the level of IL-6 in the serum...更多

Objective: To explore the regulatory effect of OX-2 membrane glycoprotein on chronic inflammation in patients with coronary heart disease complicated with diabetes mellitus . Methods: A total of 60 patients were enrolled in this study, including 20 patients with CHD, 20 patients with DM, and 20 patients with CHD complicated with DM, all of whom met the inclusion criteria. The concentration of CD200 molecules in the serum of each group was determined by ELISA, and the level of IL-6 in the serum was measured by flow cytometry. The two sets of data were analyzed and compared to investigate the inhibitory regulatory effect of CD200 on chronic inflammation. Results: The data from the three groups of patients with coronary heart disease , diabetes mellitus , and CHD complicated with DM were all higher than the normal reference values . The level of IL-6 in the CHD complicated with DM group was significantly higher than that in the CHD group , with a statistically significant difference . The level of IL-6 in the CHD complicated with DM group was also significantly higher than that in the DM group , with a statistically significant difference . Moreover, the level of IL-6 in the DM group was significantly higher than that in the CHD group , also with a statistically significant difference . The concentration of CD200 molecules in the CHD group was significantly higher than that in the CHD complicated with DM group , with a statistically significant difference . The molecular concentration of CD200 in the diabetic group was higher than that in coronary heart disease complicated with diabetes , there was a significant difference . The concentration of CD200 molecules in the CHD group was significantly higher than that in the DM group , with a statistically significant difference . Spearman correlation analysis revealed a negative correlation between the serum CD200 molecule concentration and IL-6 molecule concentration in patients with CHD ; Similarly, a negative correlation was observed between serum CD200 molecule concentration and IL-6 molecule concentration in patients with DM , as well as in patients with CHD complicated with DM . The serum CD200 molecule concentrations in all three patient groups showed a negative correlation with IL-6 molecule concentrations . Conclusion: CD200 exerts inhibitory regulatory effects on IL-6, effectively controlling inflammation and alleviating the pathological progression of atherosclerosis. Research on CD200 provides new strategies for the clinical treatment of patients with coronary heart disease combined with diabetes. It is also predicted that the development of agonists targeting the CD200-CD200R axis is expected to delay disease progression in patients with coronary heart disease combined with diabetes.收起

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