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作者

Daoxia Guo Zhengbao Zhu Chongke Zhong Hao Peng Aili Wang Tian Xu Yanbo Peng Tan Xu Chung-Shiuan Chen Qunwei Li Zhong Ju Deqin Geng Jing Chen Yonghong Zhang Jiang He

作者单位

From the Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China (D.G., Z.Z., C.Z., H.P., A.W., Y.Z., Tan Xu, Y.Z.). Department of Neurology, Affiliated Hospital of Nantong University, Jiangsu, China (Tian Xu). Department of Neurology, Affiliated Hospital of Hebei United University, China (Y.P.). Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.Z., C.-S.C., J.C., J.H.). Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong, China (Q.L.). Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia, China (Z.J.). Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, China (D.J.). Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C., J.H.).

刊名

Stroke

年份

2019

页码

STROKEAHA118024631

ISSN

1524-4628

关键词

Netrin-1 biomarkers blood-brain barrier ischemic stroke prognosis

分类号

616.1

摘要

Background and Purpose- Previous experimental studies suggested that serum netrin-1 was associated with the progression of ischemic stroke. Knowledge about netrin-1 among ischemic stroke patients may provide new ideas for the prognostic assessment of ischemic stroke. The aim of this study was to investigate the association between serum netrin-1 and prognosis of ischemic stroke. Methods- Serum netrin-1 levels at baseline were measured for 3346 ischemic stroke patients from the CATIS , and all pa...更多

Background and Purpose- Previous experimental studies suggested that serum netrin-1 was associated with the progression of ischemic stroke. Knowledge about netrin-1 among ischemic stroke patients may provide new ideas for the prognostic assessment of ischemic stroke. The aim of this study was to investigate the association between serum netrin-1 and prognosis of ischemic stroke. Methods- Serum netrin-1 levels at baseline were measured for 3346 ischemic stroke patients from the CATIS , and all patients were followed up at 3 months after stroke onset. The primary outcome was a combination of death and major disability within 3 months after stroke onset. Results- Up to 3 months after stroke onset, 845 patients experienced death or major disability. After adjustment for baseline National Institutes of Health Stroke Scale score and other potential confounders, elevated serum netrin-1 was associated with a decreased risk of primary outcome when 2 extreme quartiles were compared. Each SD increase of log-transformed netrin-1 was associated with 17% decreased risk of primary outcome. Multivariable-adjusted spline regression models showed a negative linear dose-response relationship between serum netrin-1 and the risk of primary outcome . Adding netrin-1 quartile to a model containing conventional risk factors improved risk prediction for primary outcome . Conclusions- Elevated serum netrin-1 levels were associated with improved prognosis at 3 months after ischemic stroke, suggesting that serum netrin-1 may be a potential prognostic biomarker for ischemic stroke. Further studies from other samples of ischemic stroke patients are needed to replicate our findings and to clarify the potential mechanisms. Clinical Trial Registration- URL: https://www.clinicaltrials.gov . Unique identifier: NCT01840072.收起

学科

【SCI学科】CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2018年:6.046;2017年:6.239;2016年:6.032;2015年:5.787;2014年:5.761

文献类型

期刊

浏览量

10