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作者

Zhengbao Zhu Daoxia Guo Chongke Zhong Aili Wang Xuewei Xie Tan Xu Chung-Shiuan Chen Yanbo Peng Hao Peng Qunwei Li Zhong Ju Deqin Geng Jing Chen Liping Liu Yilong Wang Yonghong Zhang Jiang He

作者单位

From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.-S.C., J.C., J.H.) *These authors contributed equally to this article. Search for more papers by this author From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) *These authors contributed equally to this article. Search for more papers by this author From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Search for more papers by this author From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Search for more papers by this author Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.X., L.L., Y.W.) Search for more papers by this author From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Search for more papers by this author Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.-S.C., J.C., J.H.) Search for more papers by this author Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei (Y.P.) Search for more papers by this author From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Search for more papers by this author Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong, China (Q.L.) Search for more papers by this author Department of Neurology, Kerqin District First People’s Hospital of Tongliao City, Inner Mongolia, China (Z.J.) Search for more papers by this author Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, China (D.G.) Search for more papers by this author Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.-S.C., J.C., J.H.) Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C., J.H.). Search for more papers by this author Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.X., L.L., Y.W.) Search for more papers by this author Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.X., L.L., Y.W.) Search for more papers by this author Correspondence to Yonghong Zhang, MD, PhD, Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123, China. Email E-mail Address: [email protected] From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.) Search for more papers by this author Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.-S.C., J.C., J.H.) Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C., J.H.). Search for more papers by this author

刊名

Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)

年份

2019

卷号

Vol.39 No.2

页码

285-293

关键词

humans dickkopf-1 stroke biomarkers prognosis

摘要

Serum Dkk-1 level has been shown to be elevated in patients with ischemic stroke, but its impact on clinical outcomes of ischemic stroke remains unclear. The aim of this study is to investigate the association between serum Dkk-1 and prognosis of ischemic stroke. We measured serum Dkk-1 levels in 3178 patients with ischemic stroke from CATIS . The primary outcome was a combination of all-cause mortality and major disability at 1 year after stroke. Secondary outcomes were stroke recurrence and ...更多

Serum Dkk-1 level has been shown to be elevated in patients with ischemic stroke, but its impact on clinical outcomes of ischemic stroke remains unclear. The aim of this study is to investigate the association between serum Dkk-1 and prognosis of ischemic stroke. We measured serum Dkk-1 levels in 3178 patients with ischemic stroke from CATIS . The primary outcome was a combination of all-cause mortality and major disability at 1 year after stroke. Secondary outcomes were stroke recurrence and vascular events. After multivariate adjustment, elevated Dkk-1 levels were associated with an increased risk of primary outcome when 2 extreme quartiles were compared. Each SD increase of log-transformed Dkk-1 was associated with 12% increased risk of primary outcome. Multiple-adjusted spline regression model showed a linear association between serum Dkk-1 and risk of primary outcome . Subgroup analyses further confirmed these associations. The addition of serum Dkk-1 to conventional risk factors improved the predictive power for primary outcome . High serum Dkk-1 levels at baseline were associated with poor prognosis at 1 year after ischemic stroke, suggesting that serum Dkk-1 may be a potential prognostic biomarker for ischemic stroke. Further studies from other samples of patients with ischemic stroke are needed to replicate our findings and to clarify the potential mechanisms.收起

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