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作者

Zhu Zhengbao Guo Daoxia Zhong Chongke Wang Aili Xie Xuewei Xu Tan Chen Chung-Shiuan Peng Yanbo Peng Hao Li Qunwei Ju Zhong Geng Deqin Chen Jing Liu Liping Wang Yilong Zhang Yonghong He Jiang

作者单位

From the Department of Epidemiology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (Z.Z., D.G., C.Z., A.W., T.X., H.P., Y.Z.). Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Z.Z., C.-S.C., J.C., J.H.). Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.X., L.L., Y.W.). Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei (Y.P.). Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong, China (Q.L.). Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia, China (Z.J.). Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, China (D.G.). Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.C., J.H.).

刊名

Arteriosclerosis, thrombosis, and vascular biology

年份

2018

页码

ATVBAHA118311960

ISSN

1524-4636

关键词

humans odds ratio prognosis risk factors stroke

摘要

Objective- Serum Dkk-1 level has been shown to be elevated in patients with ischemic stroke, but its impact on clinical outcomes of ischemic stroke remains unclear. The aim of this study is to investigate the association between serum Dkk-1 and prognosis of ischemic stroke. Approach and Results- We measured serum Dkk-1 levels in 3178 patients with ischemic stroke from CATIS . The primary outcome was a combination of all-cause mortality and major disability at 1 year after stroke. Secondary out...更多

Objective- Serum Dkk-1 level has been shown to be elevated in patients with ischemic stroke, but its impact on clinical outcomes of ischemic stroke remains unclear. The aim of this study is to investigate the association between serum Dkk-1 and prognosis of ischemic stroke. Approach and Results- We measured serum Dkk-1 levels in 3178 patients with ischemic stroke from CATIS . The primary outcome was a combination of all-cause mortality and major disability at 1 year after stroke. Secondary outcomes were stroke recurrence and vascular events. After multivariate adjustment, elevated Dkk-1 levels were associated with an increased risk of primary outcome when 2 extreme quartiles were compared. Each SD increase of log-transformed Dkk-1 was associated with 12% increased risk of primary outcome. Multiple-adjusted spline regression model showed a linear association between serum Dkk-1 and risk of primary outcome . Subgroup analyses further confirmed these associations. The addition of serum Dkk-1 to conventional risk factors improved the predictive power for primary outcome . Conclusions- High serum Dkk-1 levels at baseline were associated with poor prognosis at 1 year after ischemic stroke, suggesting that serum Dkk-1 may be a potential prognostic biomarker for ischemic stroke. Further studies from other samples of patients with ischemic stroke are needed to replicate our findings and to clarify the potential mechanisms.收起

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