获取途径

作者

Sun, Y. Li, T. Zhang, Y. Zhang, Q.

作者单位

Department of General Surgery, Laiwu Hospital Affiliated to Taishan Medical College, Laiwu, Shandong, China

刊名

Medical Science Monitor

年份

2016

卷号

Vol.22

页码

5035-5040

ISSN

1234-1010;1643-3750

关键词

Epidermal growth factor Left Receptor Triple negative breast neoplasms Ventricular dysfunction

摘要

Background: The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 overexpression. Material/Methods: A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab . All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions w...更多

Background: The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 overexpression. Material/Methods: A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab . All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions were estimated using echocardiography before the T treatment and every 3 months. General clinical data and above parameters were collected and reviewed as analysis. Results: The mean value of LVEFs with baseline was higher than those at other time points. All LVEFs were more than 50% during the course of trastuzumab treatment. The decline scope ≥15% of LVEFs ranged from 2 months to 16 months, and the ratios were counted for 3.1% at 2 months, 4.3% at 6 months, 3.8% at 10 months, and 5.4% at 16 months. Furthermore, a larger decrease of LVEF during the course occurred mainly in the patients with cumulative dose of A >300 mg/m 2 , without CPD and 16-month duration of T treatment. There was a strong correlation between cumulative dose of A, cyto/cardio-protection drugs , duration of T, and the change of LVEF , which indicated that 3 factors may be associated with the change in LVEF . Conclusions: The LVEF in patients with trastuzumab treatment was significantly decreased, which may be seen as a favorable benefit-risk ratio for patients undergoing long-term trastuzumab treatment.收起

文献类型

期刊

浏览量

18