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作者

Sun, Y. Li, T. Zhang, Y. Zhang, Q.

作者单位

Department of General Surgery, Laiwu Hospital Affiliated to Taishan Medical College, Laiwu, Shandong, China

刊名

Medical Science Monitor

年份

2016

卷号

Vol.22

页码

5035-5040

ISSN

1234-1010;1643-3750

关键词

Epidermal growth factor Left Receptor Triple negative breast neoplasms Ventricular dysfunction

摘要

Background: The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 overexpression. Material/Methods: A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab . All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions w...更多

Background: The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 overexpression. Material/Methods: A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab . All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions were estimated using echocardiography before the T treatment and every 3 months. General clinical data and above parameters were collected and reviewed as analysis. Results: The mean value of LVEFs with baseline was higher than those at other time points. All LVEFs were more than 50% during the course of trastuzumab treatment. The decline scope ≥15% of LVEFs ranged from 2 months to 16 months, and the ratios were counted for 3.1% at 2 months, 4.3% at 6 months, 3.8% at 10 months, and 5.4% at 16 months. Furthermore, a larger decrease of LVEF during the course occurred mainly in the patients with cumulative dose of A >300 mg/m 2 , without CPD and 16-month duration of T treatment. There was a strong correlation between cumulative dose of A, cyto/cardio-protection drugs , duration of T, and the change of LVEF , which indicated that 3 factors may be associated with the change in LVEF . Conclusions: The LVEF in patients with trastuzumab treatment was significantly decreased, which may be seen as a favorable benefit-risk ratio for patients undergoing long-term trastuzumab treatment.收起

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