Systematical NMR analysis of swainsonine, a mycotoxin from endophytic fungus Alternaria oxytropis

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作者: Xiangmei Tan, Yanduo Wang, Zhenliang Liu, Liliang Liu, Meng Yu, Gang Ding

作者单位: School of Pharmaceutical Science, Taishan Medical University, Tai'an, China. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Affiliations College of Chemical and Pharmaceutical Engineering, Taishan Medical University, Tai'an, China.

关键词: Alternaria oxytropis NMR endophytic fungus structural elucidation swainsonine.

摘要: Swainsonine , a unique indolizine with poly-hydroxyl groups, was re-isolated from the plant endophytic fungus Alternaria oxytropis. The structure was systematically elucidated by NMR spectra ; 1 H NMR spectra of the modified Mosher's products were first used to determine the absolute configuration of SW. More importantly, the complex coupled features of H-7α, H-7β, and H-6α in the 1 H NMR spectrum of were analyzed in details, which will provide aids for the planar and relative configuratio...更多; Swainsonine , a unique indolizine with poly-hydroxyl groups, was re-isolated from the plant endophytic fungus Alternaria oxytropis. The structure was systematically elucidated by NMR spectra ; 1 H NMR spectra of the modified Mosher's products were first used to determine the absolute configuration of SW. More importantly, the complex coupled features of H-7α, H-7β, and H-6α in the 1 H NMR spectrum of were analyzed in details, which will provide aids for the planar and relative configuration determination of analogs.收起

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