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作者

Pian Jin, Fucheng Zhu, Mi Jiang, Makoto Takafuji, Hirotaka Ihara, Lei Nie, Houmei Liu

作者单位

Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan. ⁴ Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong, China. nielei2004@sdu.edu.cn. ⁵ Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong, China. hmliu@sdu.edu.cn. Affiliations ¹ Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong, China. ² Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, 250117, Shandong, China. ³ Faculty of Advanced Science and Technology, Kumamoto University, 2-39

刊名

Mikrochimica acta

年份

2022

卷号

Vol.189 No.11

页码

401

ISSN

1436-5073

关键词

Adsorbent Berberine Carbonized polymer Solid-phase extraction Urine analysis

摘要

In view of the limitations of existing berberine solid-phase extraction adsorbents, this paper proposes a novel carbonized π-conjugated polymer-coated porous silica adsorbent with simple process and low cost for efficient extraction of berberine by multiple interactions. Characterization methods, including Brunner-Emmet-Teller measurement, thermogravimetric analysis, X-ray photoelectron spectroscopy, and scanning electron microscopy techniques, were used to verify the successful modification of...更多

In view of the limitations of existing berberine solid-phase extraction adsorbents, this paper proposes a novel carbonized π-conjugated polymer-coated porous silica adsorbent with simple process and low cost for efficient extraction of berberine by multiple interactions. Characterization methods, including Brunner-Emmet-Teller measurement, thermogravimetric analysis, X-ray photoelectron spectroscopy, and scanning electron microscopy techniques, were used to verify the successful modification of carbonized π-conjugated polymer on the surface of porous silica. The berberine was selected as target molecule, and the adsorption mechanism and process were investigated through adsorption kinetics, adsorption isotherms, and thermodynamic studies. The fitting results show that the adsorption of berberine by SiO@C-π-CP well conforms to the pseudo-second-order and Langmuir models. By optimizing the main SPE parameters, the SPE method based on SiO@C-π-CP was developed. Excellent results were obtained, including low limit of detection and limit of quantification , wide linearity , and satisfactory relative standard deviations of inter-day and intra-day . Finally, the SiO@C-π-CP also has been successfully used to the enrichment of berberine in real urine samples. This research makes clear that SiO@C-π-CP has outstanding potential for trace enrichment of berberine alkaloids.收起

学科

【SCI学科】CHEMISTRY, ANALYTICAL

影响因子

2001年:1.05;2000年:1.303;1999年:0.866;1998年:0.716;1997年:1.087

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