The role of complement in nonalcoholic fatty liver disease

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作者: Zhenya Guo, Xiude Fan, Jianni Yao, Stephen Tomlinson, Guandou Yuan, Songqing He

作者单位: Affiliations ¹ Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ² Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, China. ³ Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Guangxi Medical University, Nanning, China. ⁴ Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ⁵ Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.

关键词: complement system inflammation liver nonalcoholic fatty liver disease site-targeted inhibitor.

摘要: Nonalcoholic fatty liver disease has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved...更多; Nonalcoholic fatty liver disease has become a leading cause of chronic liver diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis, cirrhosis or even hepatocellular carcinoma. Although the pathogenesis of NAFLD is incompletely understood, insulin resistance and lipid metabolism disorder are implicated. The complement system is an essential part of the immune system, but it is also involved in lipid metabolism. In particular, activation of the alternative complement pathway and the production of complement activation products such as C3a, C3adesArg and C5a, are strongly associated with insulin resistance, lipid metabolism disorder, and hepatic inflammation. In this review, we briefly summarize research on the role of the complement system in NAFLD, aiming to provide a basis for the development of novel therapeutic strategies for NAFLD.收起

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