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作者

Wei Shi, Yong Wang, Wei Xia, Baoyan Liu, Meng Ni, Jingyi Shen, Yujun Bai, Guixiang Weng, Wenju Liu, Shuanghu Yuan, Xin Gao

作者单位

Building, Jinan New District, Jinan, 250101, Shandong, China. xingaosam@16 Affiliations ¹ Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou New District, Suzhou, 215163, Jiangsu, China. ² Jinan Guoke Medical Engineering and Technology Development Co., Ltd., Pharmaceutical Valley New Drug Creation Platform, No. Building, Jinan New District, Jinan, 250101, Shandong, China. ³ Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. ⁴ Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. ⁵ Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. ⁶ Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China. ⁷ Linyi People's Hospital, Linyi, Shandong, China. ⁸ Liaocheng People's Hospital, Liaocheng, Shandong, China. ⁹ Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. yuanshuanghu@sina.com. ¹⁰ Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. yuanshuanghu@sina.com. ¹¹ Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou New District, Suzhou, 215163, Jiangsu, China. xingaosam@16 com. com. ¹² Jinan Guoke Medical Engineering and Technology Development Co., Ltd., Pharmaceutical Valley New Drug Creation Platform, No.

刊名

Journal of neuro-oncology

年份

2022

ISSN

1573-7373

关键词

Brain metastases Non-small-cell lung cancer Radiotherapy Small-cell lung cancer Spatial distribution.

摘要

Purpose: This study aims to investigate the spatial distribution difference of brain metastases between small-cell lung cancer and non-small-cell lung cancer and to identify the metastatic risk in brain regions. Methods: T1-enhanced MR images of 2997 BM from 728 eligible patients with SCLC and NSCLC were retrospectively reviewed by three independent medical institutions in China. All images were spatially normalised according to the Montreal Neurological Institute space, following BM delineat...更多

Purpose: This study aims to investigate the spatial distribution difference of brain metastases between small-cell lung cancer and non-small-cell lung cancer and to identify the metastatic risk in brain regions. Methods: T1-enhanced MR images of 2997 BM from 728 eligible patients with SCLC and NSCLC were retrospectively reviewed by three independent medical institutions in China. All images were spatially normalised according to the Montreal Neurological Institute space, following BM delineation confirmed by three senior radiologists. The brain regions in the normalised images were identified based on the merged Anatomical Automatic Labeling atlas, and all BM locations were mapped onto these brain regions. Two-tailed proportional hypothesis testing was used to compare the BM observed rate with the expected rate based on the region's volume, and metastatic risk regions were finally identified. Results: In SCLC and NSCLC, BM was mainly present in the deep white matter , cerebellar hemisphere and middle frontal gyrus . The cerebellar hemisphere was a high-risk brain region in the SCLC. The precentral gyrus, middle frontal gyrus, paracentral lobule and cerebellar hemisphere were high-risk BM in the NSCLC. The inferior frontal gyrus and the temporal pole were a low-risk brain region in the SCLC and NSCLC, respectively. Conclusion: The spatial BM distribution between SCLC and NSCLC is similar. Several critical brain regions had relatively low BM frequency in both SCLC and NSCLC, where a low-dose radiation distribution can be delivered due to adequate preoperative evaluations.收起

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期刊