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作者

Pengyu Yao Xiaoni Yang Yun Qiao

作者单位

²Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), 250014 Jinan, Shandong, China ¹Department of Traditional Chinese Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, 250000 Jinan, Shandong, China ³Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China

刊名

Reviews in Cardiovascular Medicine

年份

2024

卷号

Vol.25 No.5

页码

165

ISSN

1530-6550

关键词

diabetic cardiomyopathy (dcm) natural products pharmacology mechanism efficacy review

摘要

Diabetic cardiomyopathy is an insidious and fatal disease, imposing major financial and social burdens on affected individuals. Among the various methods proposed for the treatment of diabetic cardiomyopathy , treatments with natural products have achieved promising results due to their high efficiency and minimal side-effects. Literature was searched, analyzed, and collected using databases, including PubMed, Web of Science, Excerpt Medica, Science Direct, and Springer. In this study, we review...更多

Diabetic cardiomyopathy is an insidious and fatal disease, imposing major financial and social burdens on affected individuals. Among the various methods proposed for the treatment of diabetic cardiomyopathy , treatments with natural products have achieved promising results due to their high efficiency and minimal side-effects. Literature was searched, analyzed, and collected using databases, including PubMed, Web of Science, Excerpt Medica, Science Direct, and Springer. In this study, we reviewed the DCM-related studies on 72 representative natural products. These natural products have been confirmed to be applicable in the therapeutic intervention of DCM, acting through various mechanisms such as the amelioration of metabolic abnormalities, protecting the mitochondrial structure and function, anti-oxidant stress, anti-inflammatory, anti-fibrosis, regulation of Ca2+ homeostasis and regulation of programmed cell death. The nuclear factor kappa B , nuclear factor erythroid 2-related factor 2 , and transforming growth factor-β have been extensively studied as high frequency signaling pathways for natural product intervention in DCM. The effectiveness of natural products in treating DCM has been revealed and studied, which provides a reference for DCM-specific drug discovery.收起

文献类型

期刊