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作者

Haomeng Zhang Meng Zhang Xinyu Zhang Yuan Gao Yanling Ma

作者单位

(Shandong University Jinan China) (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) (National University of Singapore Singapore)

刊名

생체재료학회지

年份

2022

卷号

Vol.26 No.2

页码

154-175

ISSN

1226-4601

关键词

Iron-based hydrogels Biocompatibility Synergistic cancer therapy Postoperative

摘要

Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have bee...更多

Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postopera tive tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.收起

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