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作者

Xinyi Xu Cong Sun Hong Yu Guohui Yan Qingqing Zhu Xianglei Kong Yibin Pan Haoan Xu Tianshu Zheng Chi Zhou Yutian Wang Jiaxin Xiao Ruike Chen Mingyang Li Songying Zhang Hongjie Hu Yu Zou Jingshi Wang Guangbin Wang & …Dan Wu

作者单位

⁸School of Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK ⁶Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China ¹Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China ⁴Department of Radiology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China ²Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China ⁷Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou, China ⁵Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China ⁹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China ³Dalian Municipal Women and Children’s Medical Center (Group), Dalian, China

刊名

European Radiology

年份

2025

卷号

Vol.35 No.4

页码

1830-1842

关键词

Magnetic resonance imaging Neuroimaging Fetus Fetal development Brain

摘要

Objective To evaluate multisite effects on fetal brain MRI. Specifically, to identify crucial acquisition factors affecting fetal brain structural measurements and developmental patterns, while assessing the effectiveness of existing harmonization methods in mitigating site effects. Materials and methods Between May 2017 and March 2022, T2-weighted fast spin-echo sequences in-utero MRI were performed on healthy fetuses from retrospectively recruited pregnant volunteers on four different scann...更多

Objective To evaluate multisite effects on fetal brain MRI. Specifically, to identify crucial acquisition factors affecting fetal brain structural measurements and developmental patterns, while assessing the effectiveness of existing harmonization methods in mitigating site effects. Materials and methods Between May 2017 and March 2022, T2-weighted fast spin-echo sequences in-utero MRI were performed on healthy fetuses from retrospectively recruited pregnant volunteers on four different scanners at four sites. A generalized additive model was used to quantitatively assess site effects, including field strength , manufacturer , in-plane resolution , and slice thickness , on subcortical volume and cortical morphological measurements, including cortical thickness, curvature, and sulcal depth. Growth models were selected to elucidate the developmental trajectories of these morphological measurements. Welch’s test was performed to evaluate the influence of site effects on developmental trajectories. The comBat-GAM harmonization method was applied to mitigate site-related biases. Results The final analytic sample consisted of 340 MRI scans from 218 fetuses . GAM results showed that lower FS and lower spatial resolution led to overestimations in selected brain regions of subcortical volumes and cortical morphological measurements. Only the peak cortical thickness in developmental trajectories was significantly influenced by the effects of FS and R. Notably, ComBat-GAM harmonization effectively removed site effects while preserving developmental patterns. Conclusion Our findings pinpointed the key acquisition factors in in-utero fetal brain MRI and underscored the necessity of data harmonization when pooling multisite data for fetal brain morphology investigations. Key Points Question How do specific site MRI acquisition factors affect fetal brain imaging? Finding Lower FS and spatial resolution overestimated subcortical volumes and cortical measurements. Cortical thickness in developmental trajectories was influenced by FS and in-plane resolution. Clinical relevance This study provides important guidelines for the fetal MRI community when scanning fetal brains and underscores the necessity of data harmonization of cross-center fetal studies.收起

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